{"id":"W2022413799","doi":"10.1038/mt.2012.94","title":"Modulation of eIF5A Expression Using SNS01 Nanoparticles Inhibits NF-κB Activity and Tumor Growth in Murine Models of Multiple Myeloma","year":2012,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Transfection; Multiple myeloma; Apoptosis; Small interfering RNA; Cancer research; MAPK/ERK pathway; Messenger RNA; Biology; RNA interference; Cell culture; Molecular biology; Chemistry; Phosphorylation; Cell biology; RNA; Biochemistry; Immunology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001257279,0.0001074486,0.0001516854,0.00005342499,0.00002514453,0.000003840677,0.00006844421,0.0000591051,0.000001631734],"category_scores_gemma":[0.00002023706,0.0001002644,0.00004094532,0.0001063389,0.00005604504,0.0000176537,0.00005849586,0.00003702635,1.798377e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004502674,"about_ca_system_score_gemma":0.00001573311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007847681,"about_ca_topic_score_gemma":0.000003667257,"domain_scores_codex":[0.9993348,0.00006716135,0.0001761235,0.0001647372,0.0000956247,0.000161588],"domain_scores_gemma":[0.9995865,0.00000827297,0.0001111494,0.000199553,0.00004507675,0.00004946972],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008396119,0.0001881774,0.006957585,0.00001449776,0.000009814884,2.420798e-7,0.00009208939,0.000481831,0.9896379,0.0001374754,0.000001067994,0.002395401],"study_design_scores_gemma":[0.0007361417,0.00003832189,0.02657879,0.00001603701,0.000005013966,0.000002809576,0.00001382679,0.003958838,0.968258,0.0002701012,0.00002462475,0.00009755714],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877973,0.001789134,0.01013664,0.00001576715,0.00001776407,0.00020285,0.00001383477,0.000004285936,0.00002240696],"genre_scores_gemma":[0.9973824,0.0001301396,0.002377921,0.00002786522,0.00002806743,0.00001849507,0.00001460667,0.00001633596,0.000004170683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02137992,"threshold_uncertainty_score":0.4088663,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02071893910134308,"score_gpt":0.2605098103307347,"score_spread":0.2397908712293916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}