{"id":"W2022423993","doi":"10.1016/j.tcm.2006.01.004","title":"Assembling Pieces of the Cardiac Puzzle; Calreticulin and Calcium-Dependent Pathways in Cardiac Development, Health, and Disease","year":2006,"lang":"en","type":"review","venue":"Trends in Cardiovascular Medicine","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research; Faculty of Medicine and Dentistry, University of Alberta; Heart and Stroke Foundation of Canada","keywords":"Calreticulin; Endoplasmic reticulum; Myocardin; GATA6; Cell biology; Biology; Enhancer; Calsequestrin; Calcium-binding protein; Heart development; Transcription factor; Ryanodine receptor; Regulator; Internal medicine; Serum response factor; Medicine; Calcium; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001050654,0.001237454,0.002372536,0.002057465,0.0005502978,0.001974978,0.001690394,0.002378654,0.004267146],"category_scores_gemma":[0.001160224,0.0004159053,0.0003878259,0.00279631,0.001338661,0.003579387,0.001118762,0.00380615,0.003010601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001117814,"about_ca_system_score_gemma":0.001415625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001735491,"about_ca_topic_score_gemma":0.004590664,"domain_scores_codex":[0.9997733,0.00003718164,0.00002815405,0.00004032051,0.0001001359,0.00002100144],"domain_scores_gemma":[0.9994248,0.0002453465,0.00005121193,0.00001773255,0.000160525,0.0001003715],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001461589,0.00007062878,0.0002159125,0.006089979,0.00008379365,0.0002811087,0.0001216871,0.0004936103,0.002322724,0.00869034,0.1406512,0.8408328],"study_design_scores_gemma":[0.00002474977,0.00003253264,0.0005736644,0.001419204,0.00004755429,0.0006416271,0.0001190561,0.0001178791,0.0002131431,0.006489722,0.9903015,0.00001946481],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00006685412,0.9972881,0.0001878503,0.001306281,0.000491353,0.000002052852,0.000010334,0.000009388611,0.0006377525],"genre_scores_gemma":[0.0003191714,0.9975536,0.0002692146,0.000541784,0.000580931,0.000003676132,0.00001902147,0.000001690169,0.0007108968],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004267146,"threshold_uncertainty_score":0.01427507,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05503087212542188,"score_gpt":0.3258466121827233,"score_spread":0.2708157400573014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}