{"id":"W2022437900","doi":"10.1111/j.1399-0004.2007.00841.x","title":"Validation study of the <scp>lambda</scp> model for predicting the <i>BRCA1</i> or <i>BRCA2</i> mutation carrier status of North American Ashkenazi Jewish women","year":2007,"lang":"en","type":"article","venue":"Clinical Genetics","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Lunenfeld-Tanenbaum Research Institute; Cancer Care Ontario; Mount Sinai Hospital","funders":"National Cancer Institute; National Institutes of Health; Huntsman Cancer Institute","keywords":"Confidence interval; Population; Lambda; Mutation; Receiver operating characteristic; Medicine; Family history; Breast cancer; Genetics; Oncology; Cancer; Internal medicine; Gynecology; Demography; Statistics; Mathematics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.03832763,0.001003708,0.0006676201,0.0008781818,0.0003963104,0.0006411645,0.001062617,0.0007809842,0.0004964818],"category_scores_gemma":[0.04051106,0.0004049759,0.0008784575,0.0004121758,0.0006906656,0.0004895978,0.001157996,0.001032679,0.0002515698],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007461698,"about_ca_system_score_gemma":0.001341164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009261307,"about_ca_topic_score_gemma":0.007058683,"domain_scores_codex":[0.9905576,0.008065858,0.0002366797,0.0005005595,0.0004299413,0.0002094593],"domain_scores_gemma":[0.9316788,0.05870016,0.001415495,0.003290579,0.004057742,0.0008572028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005853876,0.001996999,0.6862683,0.0002280053,0.00190389,0.0005275128,0.001134147,0.2296813,0.003867802,0.0008376295,0.00421359,0.06348698],"study_design_scores_gemma":[0.0004193119,0.002290559,0.08700702,0.00006914053,0.0001864855,0.0002521032,0.0002550131,0.9059933,0.002195386,0.0005670682,0.0007213951,0.000043207],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991838,0.0001270544,0.007151391,0.00007854407,0.00001393384,0.00007332517,0.0001973626,0.00008842798,0.0004319589],"genre_scores_gemma":[0.9943025,0.00004527638,0.004706233,0.00004207636,0.000007280783,0.00004017911,0.0006686861,0.00002163738,0.000166246],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03832763,"threshold_uncertainty_score":0.2026983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03872205806611884,"score_gpt":0.3499097931299661,"score_spread":0.3111877350638473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}