{"id":"W2022437900","doi":"10.1111/j.1399-0004.2007.00841.x","title":"Validation study of the <scp>lambda</scp> model for predicting the <i>BRCA1</i> or <i>BRCA2</i> mutation carrier status of North American Ashkenazi Jewish women","year":2007,"lang":"en","type":"article","venue":"Clinical Genetics","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Lunenfeld-Tanenbaum Research Institute; Cancer Care Ontario; Mount Sinai Hospital","funders":"National Cancer Institute; National Institutes of Health; Huntsman Cancer Institute","keywords":"Confidence interval; Population; Lambda; Mutation; Receiver operating characteristic; Medicine; Family history; Breast cancer; Genetics; Oncology; Cancer; Internal medicine; Gynecology; Demography; Statistics; Mathematics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001214764,0.0001881574,0.0002991234,0.00003357414,0.0001494094,0.00001758902,0.0004718621,0.0001172574,0.000001113411],"category_scores_gemma":[0.00183326,0.000126657,0.0001604412,0.0003961604,0.0004419756,0.000005106754,0.000210809,0.0001837104,3.961427e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007014065,"about_ca_system_score_gemma":0.0005423132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000177343,"about_ca_topic_score_gemma":0.0007780524,"domain_scores_codex":[0.9974901,0.0001959346,0.001072456,0.0004319811,0.0003518152,0.0004577061],"domain_scores_gemma":[0.9971142,0.0006076035,0.0008213978,0.0008024795,0.0005299779,0.0001243813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002787345,0.0008973735,0.8077326,0.00007194625,0.0005343967,8.378081e-7,0.005634904,0.1032248,0.008922592,0.00000759463,0.002345146,0.07034911],"study_design_scores_gemma":[0.005206871,0.006900006,0.808457,0.00002892849,0.0006221019,0.000007484097,0.01239306,0.034505,0.1182385,0.0002778182,0.01305074,0.0003125405],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838758,0.0001880527,0.01408018,0.00003182405,0.0003850044,0.001135981,0.0002113429,0.00001000947,0.00008177053],"genre_scores_gemma":[0.9963157,0.0002004921,0.002305338,0.0003293873,0.0003162367,0.0001185283,0.00006370778,0.00004457932,0.0003060505],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1093159,"threshold_uncertainty_score":0.5164924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03872205806611884,"score_gpt":0.3499097931299661,"score_spread":0.3111877350638473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}