{"id":"W2022478919","doi":"10.1021/bi1007436","title":"Rational Manipulation of Amyloidogenesis Using an Atomic Level Map of Peptide−Fibril Interactions","year":2010,"lang":"en","type":"article","venue":"Biochemistry","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"","keywords":"Fibril; Peptide; Amyloid fibril; Chemistry; Rational design; Biophysics; Biochemistry; Nanotechnology; Materials science; Biology; Amyloid β; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001456624,0.0003788374,0.0002346261,0.000139823,0.0002279105,0.0003259404,0.0002760276,0.0002707062,0.0006266485],"category_scores_gemma":[0.00023047,0.0002316277,0.0001327814,0.0001016687,0.0003628115,0.0002263062,0.0002974583,0.0006042707,0.0001819017],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001925656,"about_ca_system_score_gemma":0.0002111547,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003128985,"about_ca_topic_score_gemma":0.0005143552,"domain_scores_codex":[0.9999065,0.00001451412,0.000008324399,0.00001689403,0.00003413473,0.00001958509],"domain_scores_gemma":[0.9998345,0.00004854658,0.00005996721,0.00002106716,0.00001592035,0.00001994652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00003274354,0.00001989221,0.00007675982,0.00001452063,0.000002810112,0.00003949505,0.00001008473,0.0003720503,0.9984406,0.000320578,0.00001689499,0.0006535236],"study_design_scores_gemma":[0.00001870136,0.0001361842,0.0006132149,0.000003202048,0.000008245084,0.0001034741,0.00001222345,0.004493529,0.9933269,0.0002282462,0.001047944,0.000008007568],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781076,0.0004354972,0.0195991,0.000109268,0.00003297936,0.00005685913,0.00007612265,0.0001623584,0.001420232],"genre_scores_gemma":[0.9900147,0.0004224265,0.008915175,0.00003344887,0.000004258236,0.000030054,0.00004511962,0.00003090221,0.0005039887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006266485,"threshold_uncertainty_score":0.002096355,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08806957239931035,"score_gpt":0.3599908776982844,"score_spread":0.2719213052989741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}