{"id":"W2022480787","doi":"10.1038/nmeth.1222","title":"Functional immobilization of signaling proteins enables control of stem cell fate","year":2008,"lang":"en","type":"article","venue":"Nature Methods","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":198,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"","keywords":"Leukemia inhibitory factor; Cell fate determination; Cell biology; Signal transduction; Stem cell; Embryonic stem cell; STAT3; STAT protein; Cell signaling; MAPK/ERK pathway; Transcription factor; Chemistry; Cell; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003406527,0.0007001858,0.0002715766,0.0003424813,0.0003041406,0.000988626,0.0005128045,0.0006745147,0.001694265],"category_scores_gemma":[0.0003111339,0.0003409796,0.0003857474,0.000283558,0.0006211885,0.0004758686,0.0006989557,0.0009969372,0.000715603],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006276168,"about_ca_system_score_gemma":0.0003140605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003984518,"about_ca_topic_score_gemma":0.0009616054,"domain_scores_codex":[0.9996831,0.00003901275,0.00002834164,0.00008324299,0.00009006208,0.00007614693],"domain_scores_gemma":[0.9997876,0.00006724936,0.00005302337,0.0000387393,0.00002023091,0.00003311899],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002805666,0.00001214455,0.00003661177,0.00002240794,0.000003020958,0.0000173471,0.00001434315,0.0000581672,0.9978211,0.0007967861,0.00004923313,0.00114083],"study_design_scores_gemma":[0.000005063231,0.00001789936,0.0001677633,0.000001887,0.000005284162,0.00002537172,0.000006858801,0.0004351868,0.9982131,0.00007238043,0.001046631,0.000002678299],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9270787,0.001720757,0.06117185,0.0007199858,0.000201255,0.0000721271,0.0005149727,0.0005156198,0.008004772],"genre_scores_gemma":[0.9742426,0.001108429,0.01756277,0.0001899427,0.00003928862,0.00007258303,0.0004677068,0.0001418648,0.006174838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001694265,"threshold_uncertainty_score":0.005667865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02162043426852289,"score_gpt":0.3118153454943144,"score_spread":0.2901949112257916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}