{"id":"W2022480787","doi":"10.1038/nmeth.1222","title":"Functional immobilization of signaling proteins enables control of stem cell fate","year":2008,"lang":"en","type":"article","venue":"Nature Methods","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":198,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"","keywords":"Leukemia inhibitory factor; Cell fate determination; Cell biology; Signal transduction; Stem cell; Embryonic stem cell; STAT3; STAT protein; Cell signaling; MAPK/ERK pathway; Transcription factor; Chemistry; Cell; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007554907,0.000104667,0.0001939796,0.00007274462,0.00004888398,0.000002770303,0.0001420299,0.0003314007,0.0000304141],"category_scores_gemma":[0.00008199175,0.00009096059,0.0001061187,0.000156033,0.00008892253,0.000003473584,0.0000507918,0.000201502,0.000001088218],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001079572,"about_ca_system_score_gemma":0.0001157894,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005754752,"about_ca_topic_score_gemma":8.333828e-7,"domain_scores_codex":[0.9986858,0.0004198336,0.0002482115,0.0002352785,0.0002508246,0.0001600819],"domain_scores_gemma":[0.9991586,0.00007460306,0.0001532697,0.0002383768,0.000331528,0.00004364257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001800339,0.00007315924,0.0007201458,0.0001104555,0.00004170288,0.000001478758,0.00002262388,0.001153437,0.9956372,0.00004349461,0.0001625893,0.00185369],"study_design_scores_gemma":[0.0006501239,0.0001784311,0.000721041,0.00001302942,0.00001339719,0.000007706786,0.00002105606,0.0003502125,0.9943473,0.00003243662,0.003583884,0.0000813483],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5255363,0.005373121,0.467715,0.00002876003,0.0001202518,0.0003981023,0.00002929033,0.000007041236,0.0007921436],"genre_scores_gemma":[0.9583554,0.0001176371,0.04023385,0.00003166886,0.00008283446,0.00001986561,0.00004539502,0.00001554949,0.001097795],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4328191,"threshold_uncertainty_score":0.3709265,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02162043426852289,"score_gpt":0.3118153454943144,"score_spread":0.2901949112257916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}