{"id":"W2022498785","doi":"10.1111/j.1582-4934.2010.01150.x","title":"Epac as a novel effector of airway smooth muscle relaxation","year":2010,"lang":"en","type":"article","venue":"Journal of Cellular and Molecular Medicine","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba","funders":"Canadian Institutes of Health Research; Canada Research Chairs; Rijksuniversiteit Groningen","keywords":"RHOA; Methacholine; Myosin light-chain kinase; Bronchoconstriction; RAC1; Phosphorylation; Contraction (grammar); Chemistry; Guanine nucleotide exchange factor; Cell biology; Airway; Muscle contraction; Internal medicine; Endocrinology; Medicine; Biology; GTPase; Biochemistry; Lung; Signal transduction; Asthma; Anesthesia","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005753077,0.0001177133,0.0002273351,0.0001051383,0.00003244958,0.000005568796,0.00009486105,0.0001323793,0.00004963586],"category_scores_gemma":[0.0004106658,0.00009081668,0.0001024653,0.00008274988,0.0001314846,0.000005773454,0.00002975297,0.0001791821,8.860777e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000415174,"about_ca_system_score_gemma":0.00007017508,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001267578,"about_ca_topic_score_gemma":0.00000196271,"domain_scores_codex":[0.9990883,0.0000435425,0.0003647731,0.0001292012,0.0002607572,0.000113394],"domain_scores_gemma":[0.9990632,0.00001452702,0.0003791721,0.0001763017,0.0002294669,0.0001373093],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007736126,0.00004650952,0.00005515767,0.00004226634,0.00003531331,0.0000231212,0.0000600756,0.00001405627,0.9947851,0.0004166632,0.0001170463,0.004327303],"study_design_scores_gemma":[0.001710479,0.0008437156,0.000846922,0.0001057153,0.00007410224,0.00009311885,0.00004573615,0.00006905982,0.9711242,0.0001641213,0.02482598,0.00009688123],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9483306,0.002998875,0.04734033,0.0004090667,0.000220548,0.0001173245,0.000002181611,0.000002476896,0.0005785668],"genre_scores_gemma":[0.9975786,0.000120091,0.001695609,0.0002034488,0.0003048373,0.000001522082,0.00001820514,0.00001576315,0.0000619349],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04924796,"threshold_uncertainty_score":0.3703397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005600980644138743,"score_gpt":0.237373475474866,"score_spread":0.2317724948307273,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}