{"id":"W2022523811","doi":"10.1038/srep05756","title":"Decipher the dynamic coordination between enzymatic activity and structural modulation at focal adhesions in living cells","year":2014,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Chemical, Bioengineering, Environmental, and Transport Systems; National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute; University of California, San Diego; University of Illinois at Urbana-Champaign; University of Toronto; Wallace H. Coulter Foundation; National Science Foundation; National Institutes of Health; Harvard University","keywords":"Förster resonance energy transfer; Focal adhesion; Lipid raft; Cell biology; Proto-oncogene tyrosine-protein kinase Src; Fibronectin; Chemistry; Lipid microdomain; Integrin; Biophysics; Extracellular matrix; Subcellular localization; Kinase; Signal transduction; Biochemistry; Cell; Membrane; Biology; Fluorescence; Cytoplasm","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002234796,0.0001872433,0.0002348119,0.0003214632,0.0001624598,0.0003515175,0.000262804,0.0003700083,0.0004773793],"category_scores_gemma":[0.000302922,0.0001423132,0.0001202882,0.0002419861,0.0003063695,0.0007546106,0.000224581,0.0005898997,0.0002079721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003855939,"about_ca_system_score_gemma":0.0001770288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005340343,"about_ca_topic_score_gemma":0.0006931138,"domain_scores_codex":[0.9999261,0.000007093671,0.000005178701,0.00002359297,0.00001919338,0.00001885441],"domain_scores_gemma":[0.9999028,0.00003705586,0.00002480473,0.00001010301,0.00001358108,0.00001163734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004009845,0.00001751487,0.0009993624,0.00005942704,0.000005434732,0.00006115164,0.0000382609,0.0004005161,0.9916781,0.0006119537,0.00004716216,0.006041071],"study_design_scores_gemma":[0.00001217859,0.0001664528,0.03635794,0.00001875167,0.00002588726,0.0003711998,0.0002176215,0.02487086,0.9336099,0.001786271,0.002535217,0.00002764529],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.966683,0.003905632,0.02742727,0.0002149282,0.00003294834,0.00002099705,0.0002287181,0.00009247563,0.001394041],"genre_scores_gemma":[0.9840215,0.003312679,0.01162249,0.00008294623,0.00003203784,0.0000341787,0.0001529414,0.00001567983,0.0007256843],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005340343,"threshold_uncertainty_score":0.002797723,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007430567719395293,"score_gpt":0.2450600376462822,"score_spread":0.2376294699268869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}