{"id":"W2022548531","doi":"10.1074/jbc.m710185200","title":"The Cdc42 Effector IRSp53 Generates Filopodia by Coupling Membrane Protrusion with Actin Dynamics","year":2008,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular Mechanics and Interactions","field":"Biochemistry, Genetics and Molecular Biology","cited_by":162,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"","keywords":"Filopodia; CDC42; Effector; Cell biology; Actin; Coupling (piping); Chemistry; Dynamics (music); Biophysics; Biology; Materials science; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008036495,0.0004016778,0.0001479909,0.0001847352,0.0001885005,0.0002526334,0.0002188224,0.0002708851,0.001212401],"category_scores_gemma":[0.00006483318,0.0001834288,0.0002455895,0.0001032314,0.0002241224,0.0001446357,0.0002579366,0.0006070238,0.0003957922],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003335086,"about_ca_system_score_gemma":0.000126799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003649448,"about_ca_topic_score_gemma":0.0006547992,"domain_scores_codex":[0.9999061,0.00001073106,0.000008889476,0.00001744052,0.00003600852,0.00002079848],"domain_scores_gemma":[0.9999431,0.000009161403,0.00001442487,0.000009449999,0.000004620889,0.00001911827],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002483595,0.00001275515,0.00009091676,0.00001124131,0.000002142178,0.00004158969,0.000003527341,0.0000606888,0.9992181,0.0001083848,0.00001997437,0.0004057589],"study_design_scores_gemma":[0.00001101351,0.00003950174,0.001332356,0.000002453181,0.000004494379,0.00008301762,0.000005364415,0.001231156,0.9962097,0.00002727168,0.001052019,0.000001519428],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993535,0.0002799126,0.003476524,0.00009399209,0.00002186423,0.00002755102,0.0002726686,0.0001214524,0.002170944],"genre_scores_gemma":[0.9963378,0.000181523,0.001443791,0.00002264915,0.000003737576,0.00002659046,0.000298224,0.00002126709,0.001664517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001212401,"threshold_uncertainty_score":0.004055858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00999782136007066,"score_gpt":0.221783233836697,"score_spread":0.2117854124766263,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}