{"id":"W2022549388","doi":"10.1016/j.cellsig.2009.11.004","title":"Serotonin 4 receptor (5-HT4R) internalization is isoform-specific: Effects of 5-HT and RS67333 on isoforms A and B","year":2009,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine","funders":"Canadian Institutes of Health Research","keywords":"Internalization; Gene isoform; Cell biology; Biology; Receptor; HEK 293 cells; Serotonin; G protein-coupled receptor; Endocytic cycle; Endocytosis; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003406436,0.0003302434,0.0004462966,0.0001947171,0.000341646,0.0004307034,0.0003956148,0.000621876,0.004517549],"category_scores_gemma":[0.0005287008,0.0005479933,0.0007742676,0.000260452,0.0005976816,0.0004126095,0.000262542,0.001045417,0.0006441548],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004472197,"about_ca_system_score_gemma":0.0004901247,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005742305,"about_ca_topic_score_gemma":0.007459955,"domain_scores_codex":[0.9996554,0.00008798618,0.00003342532,0.00005097021,0.00003682931,0.0001354732],"domain_scores_gemma":[0.9997346,0.00007016771,0.00006093463,0.00004711057,0.00002032231,0.00006680684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006548447,0.0001017245,0.0008209024,0.00004791119,0.00005953383,0.0001418985,0.00004662029,0.00008678468,0.9903735,0.0001895102,0.0002096954,0.00137355],"study_design_scores_gemma":[0.001645485,0.003530782,0.142151,0.00003383303,0.0004458481,0.002742329,0.0004349457,0.003458251,0.8413019,0.0005186504,0.003665944,0.00007112876],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979252,0.0003540989,0.0003741243,0.0001325548,0.00003078811,0.00001957724,0.0003646371,0.00002009245,0.0007789519],"genre_scores_gemma":[0.9963067,0.0004035719,0.0005781106,0.0001126874,0.00001836693,0.0000298756,0.0006297019,0.00004177427,0.001879259],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005742305,"threshold_uncertainty_score":0.0151127,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005230271928080682,"score_gpt":0.2026126590388084,"score_spread":0.1973823871107277,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}