{"id":"W2022550142","doi":"10.1371/journal.pmed.0040023","title":"Prediction of Graft-Versus-Host Disease in Humans by Donor Gene-Expression Profiling","year":2007,"lang":"en","type":"article","venue":"PLoS Medicine","topic":"Hematopoietic Stem Cell Transplantation","field":"Medicine","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; Jewish General Hospital; Institute for Research in Immunology and Cancer; Toronto General Hospital; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Canada Research Chairs; Dana Foundation","keywords":"Gene expression profiling; Graft-versus-host disease; Gene expression; Transplantation; Immunology; CD8; Biology; Gene; Hematopoietic stem cell transplantation; Hematopoietic cell; Disease; Haematopoiesis; Medicine; Immune system; Stem cell; Genetics; Pathology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005424747,0.0001734362,0.0003832917,0.0002642853,0.00003700925,0.000001989276,0.00007758821,0.0001039434,0.0002054809],"category_scores_gemma":[0.0002417318,0.0001371758,0.00004673538,0.00029709,0.000124872,0.00007782067,0.00001256587,0.0002017769,0.00001190927],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009270414,"about_ca_system_score_gemma":0.00005968804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004770246,"about_ca_topic_score_gemma":0.00001170601,"domain_scores_codex":[0.9980537,0.00003974757,0.0006752392,0.0003094808,0.0006380174,0.0002838713],"domain_scores_gemma":[0.9989383,0.0002265884,0.0001430604,0.0002989486,0.0001046957,0.0002883813],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001853217,0.0003211069,0.2256255,0.0007923294,0.00003089772,0.00007787212,0.0009564269,0.000003066283,0.7698347,0.00004128516,0.0003700046,0.00009361144],"study_design_scores_gemma":[0.01213374,0.0007645573,0.1661496,0.003306486,0.0004489814,0.000007670172,0.0007017332,0.0003896316,0.8156608,0.00003366963,0.0002463497,0.0001567729],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916654,0.0006598714,0.003230909,0.0005026586,0.0003184473,0.001125718,0.00004317384,0.00008057755,0.002373262],"genre_scores_gemma":[0.9977302,0.0002139218,0.001028355,0.00009560833,0.0002796135,0.00003650613,0.0004004816,0.00003132315,0.0001839885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0594759,"threshold_uncertainty_score":0.5593866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04023902807154861,"score_gpt":0.2886426172044172,"score_spread":0.2484035891328686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}