{"id":"W2022560734","doi":"10.1152/ajpgi.00352.2002","title":"Substrate specificities of rat oatp1 and ntcp: implications for hepatic organic anion uptake","year":2003,"lang":"en","type":"article","venue":"American Journal of Physiology-Gastrointestinal and Liver Physiology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":88,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Chenodeoxycholic acid; Taurocholic acid; Organic anion transporter 1; CYP8B1; Chemistry; Biochemistry; Bile acid; Symporter; Sulfobromophthalein; Molecular biology; Cholic acid; Biology; Transporter; Medicine; Internal medicine; Liver function tests; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003150096,0.0003098173,0.0003590651,0.0002342403,0.0001581973,0.0006041425,0.0001978361,0.0003639135,0.001126944],"category_scores_gemma":[0.0005183514,0.0002301231,0.0002384383,0.0002952714,0.0001848586,0.0003587983,0.0001738003,0.0002225044,0.000489073],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005364254,"about_ca_system_score_gemma":0.0002836899,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002534539,"about_ca_topic_score_gemma":0.002050101,"domain_scores_codex":[0.9996908,0.00009589554,0.0000353525,0.00006578615,0.00005419406,0.0000579617],"domain_scores_gemma":[0.9996735,0.00011178,0.00005419054,0.00002992646,0.00009488937,0.00003577714],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003345456,0.000004727332,0.001054655,0.00005894962,0.000007396946,0.00007123516,0.00003173032,0.000080362,0.9968411,0.0000821372,0.00001653039,0.001416754],"study_design_scores_gemma":[0.00001165286,0.0002634815,0.01152691,0.000007995207,0.00002691687,0.0006678978,0.0001005256,0.000810463,0.9850406,0.00005652292,0.00147573,0.00001130815],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918784,0.00343253,0.002659811,0.00008994684,0.00001092304,0.00001237384,0.0003615636,0.0000687033,0.001485836],"genre_scores_gemma":[0.9916735,0.00203859,0.002876505,0.00005120211,0.000009965401,0.00003168663,0.001211088,0.00004036223,0.002067138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002534539,"threshold_uncertainty_score":0.005039632,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01364925908034023,"score_gpt":0.2365054169883175,"score_spread":0.2228561579079773,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}