{"id":"W2022572438","doi":"10.1021/ml4004765","title":"In Vitro Membrane Permeation Studies and in Vivo Antinociception of Glycosylated Dmt<sup>1</sup>-DALDA Analogues","year":2014,"lang":"en","type":"article","venue":"ACS Medicinal Chemistry Letters","topic":"Neuropeptides and Animal Physiology","field":"Neuroscience","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Clinical Research Institute","funders":"National Institute on Drug Abuse","keywords":"Chemistry; In vivo; In vitro; Agonist; Pharmacology; Peptide; Transcellular; Receptor; Biochemistry; Stereochemistry; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001132479,0.0003587168,0.0001867204,0.0000977086,0.00006041265,0.0001101789,0.0001593108,0.0001684389,0.001289182],"category_scores_gemma":[0.00007936635,0.00009446892,0.0001685963,0.0001006963,0.00009775921,0.0001526286,0.00005849664,0.000322242,0.0003035103],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001439408,"about_ca_system_score_gemma":0.00008006051,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003340626,"about_ca_topic_score_gemma":0.0003223907,"domain_scores_codex":[0.9999521,0.000008601873,0.000003976553,0.000008527862,0.00001257554,0.0000143113],"domain_scores_gemma":[0.9999456,0.0000127987,0.00001945164,0.000004157806,0.000009067204,0.000008955408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001127494,0.00001874246,0.00001748731,0.00001393871,0.000001967454,0.00001381519,0.000004477839,0.00005674796,0.9992964,0.00001336683,0.00001139249,0.0004388198],"study_design_scores_gemma":[0.00001218859,0.001082312,0.001282329,0.000002674286,0.00001144665,0.00007853552,0.00001256498,0.0005233258,0.9962707,0.00000856419,0.0007125068,0.000002927462],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960011,0.0008920821,0.001595704,0.00003965613,0.00002071777,0.00002530992,0.0002353938,0.00002768528,0.001162342],"genre_scores_gemma":[0.9888996,0.002356878,0.004218604,0.000060092,0.00001596175,0.00005484666,0.0006991733,0.00002609669,0.003668887],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001289182,"threshold_uncertainty_score":0.004312754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02053090175862629,"score_gpt":0.2634997332959735,"score_spread":0.2429688315373472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}