{"id":"W2022577900","doi":"10.1002/prot.21407","title":"Crystal structure of a binary complex between human GCN5 histone acetyltransferase domain and acetyl coenzyme A","year":2007,"lang":"en","type":"article","venue":"Proteins Structure Function and Bioinformatics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Structural Genomics Consortium","funders":"Wellcome Trust","keywords":"Histone acetyltransferase; Biology; PCAF; Histone Acetyltransferases; Histone methyltransferase; Acetyltransferase; Chromatin; Histone code; P300-CBP Transcription Factors; Acetylation; Chromatin remodeling; Histone H2A; Cell biology; Biochemistry; Gene; Nucleosome","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004542724,0.001151585,0.001189454,0.0003470431,0.001099049,0.001174729,0.001774017,0.0008489859,0.007111711],"category_scores_gemma":[0.0006382469,0.0005863743,0.0003532025,0.0005695856,0.0003437551,0.0005167589,0.0006122593,0.001914142,0.001335016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002922904,"about_ca_system_score_gemma":0.001565011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01703006,"about_ca_topic_score_gemma":0.0213174,"domain_scores_codex":[0.9995772,0.00003539544,0.00001398902,0.00009094918,0.000213628,0.00006889077],"domain_scores_gemma":[0.999837,0.00003286902,0.00002204143,0.000005890102,0.0000263563,0.0000758172],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01138003,0.003281688,0.02191791,0.005247999,0.002266456,0.008172378,0.001844035,0.02990906,0.6901735,0.01794321,0.1221844,0.08567931],"study_design_scores_gemma":[0.00490683,0.002676775,0.058913,0.000765478,0.001324214,0.005921316,0.001610323,0.213923,0.3752901,0.004033315,0.3300371,0.0005985275],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9110176,0.03717093,0.009172997,0.003178695,0.001466834,0.0003720985,0.007974089,0.001858537,0.02778816],"genre_scores_gemma":[0.9264774,0.01110267,0.01286421,0.001004159,0.0001598345,0.0001754716,0.03092596,0.0002696193,0.01702079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01703006,"threshold_uncertainty_score":0.03386188,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0121404190552861,"score_gpt":0.2728035486472495,"score_spread":0.2606631295919634,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}