{"id":"W2022651196","doi":"10.1016/j.immuni.2005.09.016","title":"Human TLR-7-, -8-, and -9-Mediated Induction of IFN-α/β and -λ Is IRAK-4 Dependent and Redundant for Protective Immunity to Viruses","year":2005,"lang":"en","type":"article","venue":"Immunity","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":272,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto; Child and Family Research Institute","funders":"","keywords":"Biology; Immunity; Virology; Innate immune system; Immunology; Microbiology; Immune system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000625844,0.0001638732,0.0002757177,0.0001758956,0.0004948727,0.00002157872,0.00009942149,0.0002219168,0.000044103],"category_scores_gemma":[0.0002684834,0.0001535868,0.00003262985,0.00009839774,0.0002564941,0.0002267292,0.0001616589,0.0003031897,0.00001160988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000361228,"about_ca_system_score_gemma":0.00003658756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001307827,"about_ca_topic_score_gemma":0.0001907936,"domain_scores_codex":[0.9989181,0.0003151858,0.0003334068,0.0001905464,0.00003301556,0.0002097374],"domain_scores_gemma":[0.9992592,0.0001550152,0.0001604878,0.0002571818,0.0001416204,0.0000265235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000604782,0.00009107793,0.00040475,0.00004471854,0.0001163338,1.76831e-7,0.004199789,9.145417e-7,0.9685774,0.0001259075,0.0001165556,0.02571759],"study_design_scores_gemma":[0.001843518,0.0007590348,0.09436915,0.00006447379,0.00005350741,0.00004785278,0.001399453,0.000006286426,0.8934758,0.0003137666,0.007463255,0.0002039519],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963096,0.002151365,0.0001184631,0.0003408822,0.00007988883,0.0008283244,0.00004319059,0.0000338923,0.00009437967],"genre_scores_gemma":[0.9991804,0.000143729,0.0001445003,0.0001265015,0.00001830024,0.00007483947,0.00003834675,0.00001365367,0.0002596833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0939644,"threshold_uncertainty_score":0.6263089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02554570910320049,"score_gpt":0.2871475934912167,"score_spread":0.2616018843880162,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}