{"id":"W2022674028","doi":"10.1097/mpa.0b013e318073d1c9","title":"Activation of Exchange Protein Directly Activated by Cyclic Adenosine Monophosphate and Protein Kinase A Regulate Common and Distinct Steps in Promoting Plasma Membrane Exocytic and Granule-to-Granule Fusions in Rat Islet β Cells","year":2007,"lang":"en","type":"article","venue":"Pancreas","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":33,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Exocytosis; Forskolin; Protein kinase A; Cyclic adenosine monophosphate; Cell biology; Granule (geology); Biology; Adenosine; Chemistry; Secretion; Kinase; Biochemistry; Endocrinology; Stimulation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007373426,0.0002967255,0.0006883944,0.0003674141,0.00008545761,0.0000271478,0.00005059789,0.0001490586,0.00002734217],"category_scores_gemma":[0.0004281978,0.000265394,0.00002889168,0.0006379647,0.000125709,0.0001660184,0.00007423384,0.0002502897,0.000001771022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009559093,"about_ca_system_score_gemma":0.00003581054,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001493702,"about_ca_topic_score_gemma":0.0001754539,"domain_scores_codex":[0.9981551,0.0001509266,0.0005473121,0.0004722643,0.0002487765,0.0004255821],"domain_scores_gemma":[0.9989521,0.0002574582,0.0002078728,0.0002333656,0.00005656402,0.0002926546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001815499,0.0003236771,0.01742173,0.0007960219,0.00002204722,0.00003067031,0.001014024,0.000001101392,0.9710705,0.00001184752,0.00002702995,0.0074659],"study_design_scores_gemma":[0.005534164,0.0004833469,0.06479593,0.001905859,0.00005162591,0.00001346305,0.0002131878,0.0008541163,0.9256667,0.00005849643,0.0001835482,0.0002395079],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956284,0.000582063,0.0000203972,0.0003948525,0.00002549125,0.002928319,0.00002472581,0.00005623555,0.0003394895],"genre_scores_gemma":[0.9986789,0.00006404189,0.0004526168,0.00006635363,0.00002710068,0.0002011373,0.00005354861,0.00003793119,0.0004183213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0473742,"threshold_uncertainty_score":0.9999799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00933524647957268,"score_gpt":0.233098889160587,"score_spread":0.2237636426810144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}