{"id":"W2022706281","doi":"10.1158/1535-7163.targ-11-a143","title":"Abstract A143: ARRY-380, a selective HER2 inhibitor: From drug design to clinical evaluation.","year":2011,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency; Kingston General Hospital","funders":"","keywords":"Pharmacokinetics; Pharmacology; Kinase; Drug; Potency; Metastatic breast cancer; Tyrosine-kinase inhibitor; Medicine; Cancer; Chemistry; Breast cancer; Cancer research; Internal medicine; In vitro; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007740381,0.0008814844,0.0005790195,0.0004022447,0.0002098725,0.0006924004,0.0006731501,0.0007893565,0.01011657],"category_scores_gemma":[0.0003170384,0.0002146852,0.0003066337,0.0003015274,0.0002987877,0.0005484644,0.0003275012,0.001456329,0.003646498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006006446,"about_ca_system_score_gemma":0.001039842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008722305,"about_ca_topic_score_gemma":0.001660928,"domain_scores_codex":[0.9998198,0.00003026356,0.00001620605,0.00002730067,0.00007633419,0.00003011416],"domain_scores_gemma":[0.9998575,0.00001365498,0.00002520346,0.000006021768,0.00003868847,0.00005889906],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01182915,0.002211428,0.001269392,0.002601049,0.0001474842,0.001868326,0.0001182113,0.001043304,0.161506,0.005398604,0.07968744,0.7323197],"study_design_scores_gemma":[0.02059737,0.06957703,0.01411392,0.001089162,0.0005631208,0.01137784,0.00009026289,0.004548714,0.1835497,0.003990166,0.6903493,0.0001533844],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"other","genre_scores_codex":[0.3343767,0.481229,0.01601059,0.02135633,0.007358439,0.003293639,0.006009467,0.002073733,0.1282921],"genre_scores_gemma":[0.6512471,0.1914368,0.0165603,0.01408535,0.003812289,0.0009572844,0.006985922,0.000244576,0.1146702],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.01011657,"threshold_uncertainty_score":0.03384334,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2361001896785956,"score_gpt":0.4558990134427958,"score_spread":0.2197988237642002,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}