{"id":"W2022706396","doi":"10.1021/tx200406c","title":"Structure–Activity Relationships Imply Different Mechanisms of Action for Ochratoxin A-Mediated Cytotoxicity and Genotoxicity","year":2011,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Mycotoxins in Agriculture and Food","field":"Agricultural and Biological Sciences","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"","keywords":"Genotoxicity; Cytotoxicity; Chemistry; Carcinogen; DNA adduct; Ochratoxin A; DNA damage; Reactive oxygen species; Glutathione; DNA; Biochemistry; Oxidative stress; Molecular biology; Toxicity; Biology; In vitro; Mycotoxin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008255874,0.0001678334,0.0003373543,0.00005718743,0.0001654215,0.00001447068,0.0002840871,0.0005064024,0.0002049705],"category_scores_gemma":[0.0008791764,0.00007164069,0.00007147566,0.0004621663,0.0002615845,0.00007308176,0.0001785804,0.0007099412,0.000002635464],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001081581,"about_ca_system_score_gemma":0.00001866493,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009857941,"about_ca_topic_score_gemma":0.001098139,"domain_scores_codex":[0.9980134,0.0003972814,0.0003093418,0.0004506374,0.0002878543,0.0005415073],"domain_scores_gemma":[0.9977353,0.001722524,0.0001058647,0.00009197105,0.0001526072,0.0001917417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003107592,0.0003091574,0.002561862,0.00003218976,0.00001293421,0.000001846911,0.00009528376,1.183786e-7,0.9896789,0.00387967,0.00006518767,0.003052137],"study_design_scores_gemma":[0.0002651645,0.000541006,0.1300306,0.00001219984,0.000004879069,0.00000626298,0.000124279,0.0000749222,0.8331982,0.03558509,0.00003920984,0.0001181434],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982859,0.00003528508,0.00006836865,0.0003118318,0.0000525918,0.0007957203,0.000148088,0.00002741649,0.0002747648],"genre_scores_gemma":[0.9992626,0.00002781888,0.0003920124,0.00003629292,0.00008490825,0.000134347,0.00004493796,0.000001964641,0.00001515586],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1564806,"threshold_uncertainty_score":0.3905839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2325900233522954,"score_gpt":0.3428635731458163,"score_spread":0.1102735497935209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}