{"id":"W2022711140","doi":"10.1371/journal.pgen.1004178","title":"Nucleosome Acidic Patch Promotes RNF168- and RING1B/BMI1-Dependent H2AX and H2A Ubiquitination and DNA Damage Signaling","year":2014,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":91,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Canadian Institutes of Health Research; University of Hong Kong; University of Texas at Austin; Imperial College London; University of Texas MD Anderson Cancer Center; Cancer Prevention and Research Institute of Texas; Welch Foundation","keywords":"Chromatin; Ubiquitin; Histone; Nucleosome; DNA damage; Biology; Cell biology; Histone H2A; DNA repair; DNA; Molecular biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002755825,0.0002156132,0.0001836349,0.00004870127,0.0001555553,0.00009788637,0.0001063892,0.0001797217,0.000016741],"category_scores_gemma":[0.0001081479,0.0002163398,0.00002540789,0.00004415829,0.0001631396,0.000007451672,0.0002512163,0.0001148777,0.000003646342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008435395,"about_ca_system_score_gemma":0.00002088254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007733881,"about_ca_topic_score_gemma":0.00002457208,"domain_scores_codex":[0.9987794,0.000100739,0.0002153146,0.0004613092,0.0001685091,0.0002747758],"domain_scores_gemma":[0.9993879,0.00003048969,0.00009557711,0.0002470329,0.00007823954,0.0001607503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002092572,0.00004690131,0.006005563,0.0001439951,0.00003251807,0.00000223842,0.0002178085,0.000002866236,0.9868723,0.0002115073,0.00001322179,0.006430157],"study_design_scores_gemma":[0.0006421767,0.0005488743,0.002564819,0.00004935797,0.00004997402,0.00002472388,0.0001027089,0.002140376,0.9911972,0.0007676132,0.001615865,0.0002962696],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964655,0.002104563,0.0003482351,0.0001856547,0.00004030858,0.0003182394,0.00002670089,0.00002645967,0.000484339],"genre_scores_gemma":[0.997393,0.0006193825,0.001387963,0.0001867875,0.0002169503,0.00002489302,0.00004712499,0.00004006106,0.00008391477],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006133887,"threshold_uncertainty_score":0.8822082,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01256606229176584,"score_gpt":0.2196481182477628,"score_spread":0.2070820559559969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}