{"id":"W2022720324","doi":"10.1016/j.metabol.2003.09.009","title":"Cyclooxygenase inhibition is associated with downregulation of apolipoprotein AI promoter activity in cultured hepatoma cell line HepG2","year":2004,"lang":"en","type":"article","venue":"Metabolism","topic":"Peroxisome Proliferator-Activated Receptors","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Molecular biology; Transfection; Chloramphenicol acetyltransferase; Reporter gene; Cell culture; Gene expression; Apolipoprotein B; Hep G2; Biology; Cyclooxygenase; Promoter; Western blot; Transcription (linguistics); Gene; Chemistry; Enzyme; Endocrinology; Biochemistry; Cholesterol","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001839135,0.0002385322,0.0003026619,0.0001092059,0.00004729336,0.0000181336,0.00009170712,0.0003255611,0.00001785792],"category_scores_gemma":[0.00005231267,0.00019869,0.00008356167,0.0003366364,0.00007191149,0.00002527242,0.00005002653,0.0001946222,0.000004177662],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005521284,"about_ca_system_score_gemma":0.000115507,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002065436,"about_ca_topic_score_gemma":0.0001628689,"domain_scores_codex":[0.9987128,0.0001189617,0.0002601632,0.0003921516,0.0002366599,0.0002792556],"domain_scores_gemma":[0.999265,0.000003241127,0.0002114259,0.0002799827,0.0001602342,0.00008015258],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002367755,0.0004450778,0.0005935613,0.00002093716,0.00004810828,0.000003829422,0.0002275342,0.0002047036,0.9977891,0.00001340486,0.00003577728,0.0003811759],"study_design_scores_gemma":[0.00264612,0.0001722899,0.01030922,0.00004755182,0.00002705815,0.000004347547,0.0000142257,0.00004401553,0.9859645,0.0001510399,0.0003787281,0.0002408662],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980769,0.0002547787,0.0006603271,0.0002954631,0.00004926273,0.0004984969,0.00007343163,0.00002391218,0.00006744535],"genre_scores_gemma":[0.9985709,0.0000401833,0.0006701726,0.0001852655,0.0001318966,0.0000619913,0.0002076913,0.00003409667,0.00009776666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01182458,"threshold_uncertainty_score":0.8102341,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006042168256898617,"score_gpt":0.2218358845689589,"score_spread":0.2157937163120603,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}