{"id":"W2022729339","doi":"10.1128/jb.182.18.5091-5096.2000","title":"Metronidazole Activation Is Mutagenic and Causes DNA Fragmentation in <i>Helicobacter pylori</i> and in <i>Escherichia coli</i> Containing a Cloned <i>H. pylori rdxA</i> <sup>+</sup> (Nitroreductase) Gene","year":2000,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Helicobacter pylori-related gastroenterology studies","field":"Medicine","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Medical Research Council; National Institutes of Health; AstraZeneca Canada; AstraZeneca","keywords":"Biology; Escherichia coli; Virulence; Mutant; Mutation; Microbiology; Nitroreductase; Helicobacter pylori; Bacteria; DNA damage; DNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006170485,0.000384372,0.001094995,0.0005522391,0.00008141764,0.00003616305,0.0001131576,0.0003213127,0.0001360059],"category_scores_gemma":[0.0001286731,0.0003497573,0.00009838922,0.0003967844,0.0002727572,0.0005052713,0.00006487583,0.0008981943,0.0000103597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002850088,"about_ca_system_score_gemma":0.0001482007,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001395419,"about_ca_topic_score_gemma":0.00007082641,"domain_scores_codex":[0.9971663,0.0003521352,0.001245777,0.0004293822,0.0002158665,0.0005905714],"domain_scores_gemma":[0.998719,0.0002052773,0.0004741274,0.0002030201,0.0001800119,0.000218596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007110609,0.0003265463,0.5492926,0.00006863461,0.0006493225,0.0002950764,0.004962103,0.0001125517,0.4333721,0.000004056652,0.0002640673,0.003542376],"study_design_scores_gemma":[0.01341444,0.003019708,0.9539059,0.0003096714,0.0003422441,0.001254264,0.001658163,0.0002930064,0.02249514,0.00004713936,0.002916801,0.0003435445],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946049,0.0006153457,0.0000243673,0.004093596,0.0001459446,0.0004005288,0.00002173069,0.00002131226,0.00007227172],"genre_scores_gemma":[0.9915289,0.002074048,0.0008705207,0.0051303,0.0002582874,0.00002363354,0.0000324289,0.00004277751,0.00003909998],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4108769,"threshold_uncertainty_score":0.9998955,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01418535959894788,"score_gpt":0.2552679205525127,"score_spread":0.2410825609535649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}