{"id":"W2022729339","doi":"10.1128/jb.182.18.5091-5096.2000","title":"Metronidazole Activation Is Mutagenic and Causes DNA Fragmentation in <i>Helicobacter pylori</i> and in <i>Escherichia coli</i> Containing a Cloned <i>H. pylori rdxA</i> <sup>+</sup> (Nitroreductase) Gene","year":2000,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Helicobacter pylori-related gastroenterology studies","field":"Medicine","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Medical Research Council; National Institutes of Health; AstraZeneca Canada; AstraZeneca","keywords":"Biology; Escherichia coli; Virulence; Mutant; Mutation; Microbiology; Nitroreductase; Helicobacter pylori; Bacteria; DNA damage; DNA; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001349046,0.0003237391,0.0002421742,0.0002089261,0.000100513,0.000201245,0.0002308369,0.0004160134,0.0009978005],"category_scores_gemma":[0.000227925,0.0002406817,0.0002714146,0.0001489495,0.0001777738,0.0001003294,0.0001689244,0.0003565829,0.0003167825],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002419886,"about_ca_system_score_gemma":0.0001322138,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009146193,"about_ca_topic_score_gemma":0.0009128712,"domain_scores_codex":[0.9996158,0.00007194786,0.00004322917,0.00007137121,0.0001280494,0.0000694698],"domain_scores_gemma":[0.9997825,0.0000350818,0.00008060975,0.00003249528,0.0000294892,0.00003997636],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004477763,0.00001141577,0.0001711157,0.000008960702,0.000002676594,0.00002208557,0.000005877704,0.00001152381,0.9994143,0.000009023053,0.000007256846,0.0002909758],"study_design_scores_gemma":[0.000008643868,0.0003951649,0.006512394,0.000003379994,0.000006578228,0.0003040984,0.0000195783,0.0002711202,0.9919668,0.00001097004,0.000498335,0.000002954441],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.99735,0.0006099361,0.001196173,0.00004937724,0.00001730673,0.00001850928,0.000183184,0.00004929956,0.000526118],"genre_scores_gemma":[0.996454,0.0002986921,0.001538542,0.00003817931,0.000005967108,0.00001936314,0.0006492111,0.00002091499,0.0009751149],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009978005,"threshold_uncertainty_score":0.003338039,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01418535959894788,"score_gpt":0.2552679205525127,"score_spread":0.2410825609535649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}