{"id":"W2022765384","doi":"10.1371/journal.ppat.1004150","title":"The Inflammasome Pyrin Contributes to Pertussis Toxin-Induced IL-1β Synthesis, Neutrophil Intravascular Crawling and Autoimmune Encephalomyelitis","year":2014,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":81,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Fonds de Recherche du Québec - Santé; Multiple Sclerosis Society; Natural Sciences and Engineering Research Council of Canada; Multiple Sclerosis Society of Canada","keywords":"Inflammasome; Pyrin domain; Experimental autoimmune encephalomyelitis; Pertussis toxin; Immunology; Encephalomyelitis; Inflammation; TLR4; Innate immune system; Immune system; Biology; Medicine; Multiple sclerosis; Cell biology; Signal transduction; G protein","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002426899,0.0005207488,0.0003430795,0.0003456395,0.0002821524,0.0005798538,0.0001462364,0.000620252,0.001440567],"category_scores_gemma":[0.0002106431,0.0002285524,0.0003855767,0.0001512638,0.0004524267,0.0004548901,0.0005787348,0.0009281717,0.0005259153],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002497792,"about_ca_system_score_gemma":0.0002647394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001641206,"about_ca_topic_score_gemma":0.0002164604,"domain_scores_codex":[0.9998214,0.00003552611,0.00001772863,0.0000369385,0.00003708466,0.00005137742],"domain_scores_gemma":[0.9997383,0.0000221631,0.0001233215,0.00002090838,0.00001974921,0.0000754621],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006952444,0.00005181371,0.001100813,0.0001815051,0.00001461605,0.0008374787,0.00006772757,0.0001164935,0.9934624,0.0007021257,0.0001557814,0.002613961],"study_design_scores_gemma":[0.0002564961,0.00155588,0.1207089,0.0001347732,0.0002247091,0.009217721,0.0004870342,0.005099053,0.8313961,0.003925211,0.02695678,0.00003733084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.973139,0.01324662,0.008571764,0.001008179,0.0001240421,0.00005770497,0.0004221136,0.0001624769,0.003268053],"genre_scores_gemma":[0.9913974,0.00365921,0.001501227,0.0001381944,0.00004860615,0.00003679476,0.0003068905,0.00001972967,0.002891939],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001440567,"threshold_uncertainty_score":0.004819155,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005795253002155058,"score_gpt":0.1971798281737185,"score_spread":0.1913845751715635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}