{"id":"W2022787293","doi":"10.1186/1741-7015-11-249","title":"What if HIV were unable to develop resistance against a new therapeutic agent?","year":2013,"lang":"en","type":"article","venue":"BMC Medicine","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Dolutegravir; Drug resistance; Drug; Integrase inhibitor; Resistance mutation; Human immunodeficiency virus (HIV); Food and drug administration; Viral replication; Pharmacology; Virology; ANTIRETROVIRAL AGENTS; Antiretroviral therapy; Intensive care medicine; Virus; Viral load; Genetics; Gene; Reverse transcriptase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002919697,0.0003590941,0.0006111859,0.0002328008,0.0001174716,0.00005212746,0.0001896201,0.0001023723,0.002427791],"category_scores_gemma":[0.0002688827,0.0002432976,0.00006004264,0.0007968864,0.00007533125,0.0002553045,0.00006496242,0.0001658974,0.003714009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002569173,"about_ca_system_score_gemma":0.0006709024,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004442815,"about_ca_topic_score_gemma":0.0001612003,"domain_scores_codex":[0.9977009,0.00005424637,0.0005312977,0.0005366053,0.0006109425,0.0005660398],"domain_scores_gemma":[0.9981463,0.000146737,0.00009972592,0.0006121314,0.0002672982,0.0007278415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000237058,0.0001669153,0.01899326,0.0002205942,0.0002657901,0.0001282257,0.005488675,0.000004189312,0.001622285,0.000484703,0.9341615,0.03822675],"study_design_scores_gemma":[0.006093729,0.0001772702,0.03716464,0.002617068,0.0002167301,0.00002055853,0.003917641,0.00004295736,0.001235686,0.0005556532,0.9475482,0.0004098695],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"other","genre_scores_codex":[0.2699981,0.02905505,0.01168214,0.5514768,0.003494173,0.0083788,0.000006926794,0.0009440387,0.1249639],"genre_scores_gemma":[0.1082601,0.0012766,0.016473,0.01162241,0.0007329129,0.0002228379,0.0001531413,0.00007727656,0.8611817],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.7362177,"threshold_uncertainty_score":0.9984841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03277880346640674,"score_gpt":0.2805638879207553,"score_spread":0.2477850844543486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}