{"id":"W2022832396","doi":"10.1021/jm0708984","title":"Sulfonate Derivatives of Naphtho[2,3-<i>b</i>]thiophen-4(9<i>H</i>)-one and 9(10<i>H</i>)-Anthracenone as Highly Active Antimicrotubule Agents. Synthesis, Antiproliferative Activity, and Inhibition of Tubulin Polymerization","year":2007,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba","funders":"","keywords":"Chemistry; HeLa; Colchicine; Tubulin; IC50; In vitro; Stereochemistry; Cell culture; Cytotoxicity; K562 cells; Microtubule polymerization; Microtubule; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007626993,0.0002615576,0.0001283439,0.0001629891,0.00008640064,0.0001104593,0.0001565427,0.00013419,0.001163399],"category_scores_gemma":[0.00007953903,0.000120044,0.0001129271,0.0001570767,0.0001392569,0.0001291542,0.00009154218,0.0002075488,0.0003629214],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001584045,"about_ca_system_score_gemma":0.0001704572,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004722817,"about_ca_topic_score_gemma":0.001472228,"domain_scores_codex":[0.9999417,0.00001624012,0.000003665494,0.000008528318,0.00001712922,0.00001262603],"domain_scores_gemma":[0.9999459,0.000006333771,0.00001899949,0.000005352617,0.000008313389,0.0000151083],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000115933,0.00003992064,0.00008314997,0.00007821407,0.000005566702,0.00006056216,0.00001630198,0.0003078758,0.9944265,0.0002327948,0.0000780363,0.004555152],"study_design_scores_gemma":[0.00005272245,0.001210656,0.001678276,0.000008491163,0.00001757148,0.000271406,0.00001218825,0.0005491904,0.9893498,0.00006092562,0.006782204,0.000006612369],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764481,0.009527467,0.005177031,0.0001403636,0.00007642389,0.000129136,0.0004177907,0.00008994765,0.007993612],"genre_scores_gemma":[0.9806758,0.006628598,0.005849717,0.00006044919,0.00003085233,0.00005783454,0.0005717675,0.00001362764,0.006111243],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001163399,"threshold_uncertainty_score":0.003891945,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01589300820079943,"score_gpt":0.2582207693183848,"score_spread":0.2423277611175854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}