{"id":"W2022832396","doi":"10.1021/jm0708984","title":"Sulfonate Derivatives of Naphtho[2,3-<i>b</i>]thiophen-4(9<i>H</i>)-one and 9(10<i>H</i>)-Anthracenone as Highly Active Antimicrotubule Agents. Synthesis, Antiproliferative Activity, and Inhibition of Tubulin Polymerization","year":2007,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Synthesis and biological activity","field":"Chemistry","cited_by":49,"is_retracted":false,"has_abstract":true,"ca_institutions":"CancerCare Manitoba","funders":"","keywords":"Chemistry; HeLa; Colchicine; Tubulin; IC50; In vitro; Stereochemistry; Cell culture; Cytotoxicity; K562 cells; Microtubule polymerization; Microtubule; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008816338,0.0003185009,0.0009316042,0.00008042368,0.00009946244,0.00001768107,0.0001597481,0.000323234,0.0005531757],"category_scores_gemma":[0.00117875,0.0002520552,0.0001408061,0.0002143786,0.0007073354,0.000283709,0.0001167988,0.0004629279,6.07642e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006155627,"about_ca_system_score_gemma":0.0001221921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003641579,"about_ca_topic_score_gemma":0.000001451716,"domain_scores_codex":[0.9977984,0.00007548441,0.0008786473,0.0003269036,0.0006217298,0.0002988468],"domain_scores_gemma":[0.9965717,0.0009530985,0.001692671,0.0001699738,0.0003851014,0.0002274681],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002417059,0.0006407512,0.003003772,0.0005865705,0.0002470857,0.00004962612,0.0002726729,7.252899e-7,0.9759298,0.00001134562,0.00002934574,0.01681126],"study_design_scores_gemma":[0.00113204,0.00024555,0.01349995,0.001029571,0.0001788538,0.0002715065,0.0008319443,0.0000124874,0.9823491,0.0001392321,0.00008151451,0.0002282801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952707,0.001162359,0.0002466853,0.0004537794,0.00003650149,0.00008114954,0.00006681676,0.00001187329,0.002670077],"genre_scores_gemma":[0.9974838,0.001652767,0.0004682211,0.00004324311,0.000250343,0.000002553206,0.000008294012,0.00002143708,0.00006936902],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01658298,"threshold_uncertainty_score":0.9999931,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01589300820079943,"score_gpt":0.2582207693183848,"score_spread":0.2423277611175854,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}