{"id":"W2022852467","doi":"10.1002/chir.20662","title":"Detection and quantification of (<i>R</i>) and (<i>S</i>)‐dechloroethylifosfamide metabolites in plasma from children by enantioselective LC/MS/MS","year":2008,"lang":"en","type":"article","venue":"Chirality","topic":"Chemotherapy-induced organ toxicity mitigation","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Metabolite; Ifosfamide; Enantioselective synthesis; Chromatography; Detection limit; Enantiomer; Mass spectrometry; Nephrotoxicity; Stereochemistry; Internal medicine; Chemotherapy; Cisplatin; Toxicity; Biochemistry; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002488708,0.000176986,0.0003998954,0.0001207397,0.00007953713,0.00001115114,0.0000486153,0.0001627826,0.00001458927],"category_scores_gemma":[0.0001830351,0.0001712538,0.00004582826,0.0003049577,0.0002226532,0.0001819219,0.0000229404,0.0002288473,0.000002570747],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006547775,"about_ca_system_score_gemma":0.00004099175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002674868,"about_ca_topic_score_gemma":0.0003240958,"domain_scores_codex":[0.998702,0.00009618876,0.0003962945,0.000424635,0.0002077974,0.0001730106],"domain_scores_gemma":[0.9993009,0.0001051632,0.0001863002,0.00024047,0.00007541174,0.00009175752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001213152,0.0001063386,0.2869354,0.00001874513,0.00003723691,7.034815e-7,0.0006777518,4.643035e-7,0.7083904,0.00001714405,0.00002167744,0.003672836],"study_design_scores_gemma":[0.001020841,0.00004790211,0.4962412,0.00002118511,0.00002782629,0.00001880965,0.00002488848,0.00009507539,0.502105,0.0003012898,0.00002032185,0.00007569473],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979213,0.0007449787,0.0003170135,0.0002827742,0.00003004037,0.0004826282,0.00007827818,0.00005237776,0.00009056258],"genre_scores_gemma":[0.9984431,0.000595108,0.0006233088,0.0001155586,0.00006480196,0.00001232668,0.00009462183,0.00002253346,0.00002862937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2093058,"threshold_uncertainty_score":0.6983526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01593457205548594,"score_gpt":0.2469520575110472,"score_spread":0.2310174854555613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}