{"id":"W2022852467","doi":"10.1002/chir.20662","title":"Detection and quantification of (<i>R</i>) and (<i>S</i>)‐dechloroethylifosfamide metabolites in plasma from children by enantioselective LC/MS/MS","year":2008,"lang":"en","type":"article","venue":"Chirality","topic":"Chemotherapy-induced organ toxicity mitigation","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Metabolite; Ifosfamide; Enantioselective synthesis; Chromatography; Detection limit; Enantiomer; Mass spectrometry; Nephrotoxicity; Stereochemistry; Internal medicine; Chemotherapy; Cisplatin; Toxicity; Biochemistry; Organic chemistry; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004877313,0.000814341,0.0003678759,0.0007641788,0.0002201334,0.0003092147,0.0002531127,0.0005962512,0.00055019],"category_scores_gemma":[0.0007048925,0.0002611714,0.0003138444,0.0004444994,0.0003058483,0.0001758411,0.0001405245,0.0004181073,0.0002612456],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003684537,"about_ca_system_score_gemma":0.0004553634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001452016,"about_ca_topic_score_gemma":0.001940794,"domain_scores_codex":[0.9993799,0.0001251281,0.00004884514,0.0002046081,0.0001731565,0.00006841694],"domain_scores_gemma":[0.999653,0.00009509652,0.0001302474,0.00002197766,0.00006399229,0.00003567956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003551403,0.00003526681,0.01450833,0.00006969556,0.00006270055,0.0002926172,0.00007376877,0.0002493213,0.9745879,0.00008510619,0.0001371278,0.009543017],"study_design_scores_gemma":[0.00004988169,0.0005768345,0.04305857,0.00001421609,0.0000681089,0.003907613,0.00006987382,0.001903442,0.9477591,0.00006599969,0.002502677,0.0000236403],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9778652,0.002496914,0.01576783,0.0001339542,0.00002372426,0.00009945522,0.001869397,0.0002892095,0.001454221],"genre_scores_gemma":[0.9487469,0.001537902,0.04684721,0.0003134962,0.00002902302,0.000181008,0.001426795,0.00005897828,0.0008585333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001452016,"threshold_uncertainty_score":0.00288713,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01593457205548594,"score_gpt":0.2469520575110472,"score_spread":0.2310174854555613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}