{"id":"W2022856958","doi":"10.1039/c4md00063c","title":"Design of glycosyltransferase inhibitors targeting human<i>O</i>-GlcNAc transferase (OGT)","year":2014,"lang":"en","type":"article","venue":"MedChemComm","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Burnaby Hospital; Simon Fraser University","funders":"Université Claude Bernard Lyon 1; Centre National de la Recherche Scientifique","keywords":"Glycosyltransferase; Transferase; Biochemistry; Chemistry; Computational biology; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002464494,0.0004781938,0.0002357361,0.0001060422,0.0001132192,0.0003353621,0.0003519647,0.0002725023,0.0006439716],"category_scores_gemma":[0.0001263651,0.0001480608,0.0001782786,0.00011707,0.0002048553,0.000277133,0.000186829,0.000559251,0.0003579451],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005274676,"about_ca_system_score_gemma":0.0003400789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004227817,"about_ca_topic_score_gemma":0.001033382,"domain_scores_codex":[0.9999422,0.000009918438,0.000005343937,0.00001248337,0.00001399007,0.00001611654],"domain_scores_gemma":[0.9999574,0.000004670774,0.00001432645,0.000003010425,0.000007556842,0.00001311511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002903884,0.0001154409,0.0001806341,0.0001050902,0.00001663198,0.00008642539,0.00002260311,0.001458961,0.9833572,0.002441771,0.0005487081,0.01137608],"study_design_scores_gemma":[0.0001673236,0.001123218,0.0004017872,0.00001377048,0.00002560758,0.00028867,0.00001907689,0.003423188,0.9809991,0.0004512689,0.01307418,0.00001292297],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8910496,0.007824492,0.08683838,0.0007697004,0.000276511,0.0007903529,0.0009005955,0.0004855039,0.01106483],"genre_scores_gemma":[0.9584077,0.006649026,0.02807408,0.0003129729,0.00002606249,0.0002575489,0.001167793,0.00004085128,0.005063904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006439716,"threshold_uncertainty_score":0.003827095,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01513842923148518,"score_gpt":0.2660942009325127,"score_spread":0.2509557717010275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}