{"id":"W2022865527","doi":"10.1210/endo.142.1.7902","title":"Phosphatidylinositol-3,4,5-Trisphosphate Is Required for Insulin-Like Growth Factor 1-Mediated Survival of 3T3-L1 Preadipocytes**This work was supported by a grant (to A.S.) from the Medical Research Council of Canada.","year":2001,"lang":"en","type":"article","venue":"Endocrinology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Wortmannin; Endocrinology; Internal medicine; Protein kinase B; LY294002; PI3K/AKT/mTOR pathway; MAPK/ERK pathway; Growth factor; Programmed cell death; Biology; Adipocyte; Adipose tissue; Apoptosis; Kinase; Signal transduction; Cell biology; Medicine; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001794368,0.0004373227,0.0003519177,0.0002818996,0.000340034,0.0006247203,0.0003161899,0.0002956063,0.001357296],"category_scores_gemma":[0.0001792687,0.0002479555,0.0003576086,0.0002718403,0.0003003004,0.0002537112,0.0002563816,0.0007321855,0.001219277],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007476955,"about_ca_system_score_gemma":0.0005079517,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002861066,"about_ca_topic_score_gemma":0.004612835,"domain_scores_codex":[0.9998119,0.00002342533,0.00002000951,0.00003201588,0.00006721527,0.00004543704],"domain_scores_gemma":[0.9998235,0.00003071734,0.00004284238,0.0000183838,0.00003026849,0.00005436329],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003819669,0.00002841684,0.000234238,0.00003326101,0.000004745621,0.00009949545,0.00001649974,0.00006074656,0.9979377,0.0000664122,0.0000691497,0.00106732],"study_design_scores_gemma":[0.00008630894,0.0004166937,0.02623367,0.00001405909,0.00003761831,0.0006451276,0.0001118048,0.002175179,0.9647065,0.0001505529,0.005406967,0.00001565206],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9851666,0.004634426,0.003506905,0.000365538,0.00009949443,0.00005365045,0.002216591,0.0002409712,0.00371581],"genre_scores_gemma":[0.9893517,0.00162635,0.00235463,0.0001055299,0.00001735352,0.00006793893,0.003180817,0.00005932925,0.003236416],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002861066,"threshold_uncertainty_score":0.005688846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03953813970574752,"score_gpt":0.2777343368458848,"score_spread":0.2381961971401373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}