{"id":"W2022865527","doi":"10.1210/endo.142.1.7902","title":"Phosphatidylinositol-3,4,5-Trisphosphate Is Required for Insulin-Like Growth Factor 1-Mediated Survival of 3T3-L1 Preadipocytes**This work was supported by a grant (to A.S.) from the Medical Research Council of Canada.","year":2001,"lang":"en","type":"article","venue":"Endocrinology","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":44,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Wortmannin; Endocrinology; Internal medicine; Protein kinase B; LY294002; PI3K/AKT/mTOR pathway; MAPK/ERK pathway; Growth factor; Programmed cell death; Biology; Adipocyte; Adipose tissue; Apoptosis; Kinase; Signal transduction; Cell biology; Medicine; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006829109,0.000234808,0.0004391146,0.00004652967,0.0001539006,0.00001000493,0.000558782,0.0003166675,0.0003886211],"category_scores_gemma":[0.00155685,0.0001810361,0.000115538,0.0003613662,0.0002461638,0.000005382966,0.0002044993,0.0002169724,0.000004677159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001779004,"about_ca_system_score_gemma":0.002512235,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.08825527,"about_ca_topic_score_gemma":0.06893016,"domain_scores_codex":[0.996664,0.0002345718,0.0006178745,0.0005494383,0.001199432,0.0007347075],"domain_scores_gemma":[0.9972479,0.0004948615,0.0002073768,0.0005348383,0.001280264,0.0002347817],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.004850987,0.0005243127,0.01324344,0.00008547521,0.0008533479,0.00008724811,0.001334375,0.00001470992,0.7169753,0.0005711046,0.2501935,0.01126617],"study_design_scores_gemma":[0.002520089,0.0005587468,0.007669181,0.00004129526,0.00004578898,0.00001394168,0.0001405155,0.000131054,0.6162606,0.0001965145,0.3721605,0.000261781],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9863605,0.006023406,0.001079317,0.00347335,0.0009124835,0.0009242427,0.0009338685,0.00001622519,0.0002766071],"genre_scores_gemma":[0.9944137,0.002250885,0.0001978949,0.0004820441,0.0001693923,0.00008836244,0.0005951397,0.00003864338,0.001763907],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.121967,"threshold_uncertainty_score":0.9480594,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03953813970574752,"score_gpt":0.2777343368458848,"score_spread":0.2381961971401373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}