{"id":"W2022879400","doi":"10.1074/jbc.m110778200","title":"Translation Mediated by the Internal Ribosome Entry Site of the cat-1 mRNA Is Regulated by Glucose Availability in a PERK Kinase-dependent Manner","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Internal ribosome entry site; Eukaryotic initiation factor; EIF4E; Unfolded protein response; Protein biosynthesis; Endoplasmic reticulum; Translation (biology); Initiation factor; Biology; Cell biology; Messenger RNA; Amino acid; Protein kinase A; Eukaryotic translation; Kinase; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001769358,0.0006853924,0.0005339432,0.0004333557,0.0003331336,0.0007226011,0.0002417001,0.0003399694,0.003843789],"category_scores_gemma":[0.0002427204,0.0002424068,0.0006644806,0.0002839318,0.000324047,0.0003000399,0.000479007,0.00107396,0.003087086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009219842,"about_ca_system_score_gemma":0.0004121932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008130833,"about_ca_topic_score_gemma":0.001042027,"domain_scores_codex":[0.9996965,0.00002854911,0.00002379692,0.00009902068,0.00006383465,0.00008824789],"domain_scores_gemma":[0.9998288,0.00003190869,0.00003864267,0.00002274699,0.00004234009,0.00003557286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001910077,0.0000600459,0.0002509811,0.00009349258,0.000009601188,0.0000883036,0.00002800458,0.00006791353,0.9958246,0.0003954309,0.0003846613,0.00260607],"study_design_scores_gemma":[0.00006343421,0.0002966315,0.01997327,0.00007285737,0.00002568605,0.0004975774,0.00008636882,0.003270729,0.9576721,0.0003659458,0.01764159,0.00003384775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9463497,0.01260868,0.01727895,0.0009875211,0.001087594,0.0002238483,0.004081335,0.0009239845,0.01645833],"genre_scores_gemma":[0.9550154,0.002895693,0.007655581,0.0003226903,0.00008747747,0.0002060126,0.009479268,0.0002551153,0.02408276],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003843789,"threshold_uncertainty_score":0.01285875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01075832085257368,"score_gpt":0.2189357697060526,"score_spread":0.2081774488534789,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}