{"id":"W2022894714","doi":"10.1074/jbc.m112.411728","title":"Depletion of the Ubiquitin-binding Adaptor Molecule SQSTM1/p62 from Macrophages Harboring cftr ΔF508 Mutation Improves the Delivery of Burkholderia cenocepacia to the Autophagic Machinery","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Cystic Fibrosis Canada","keywords":"Burkholderia cenocepacia; Autophagy; Autophagosome; Biology; Sequestosome 1; Lysosome; Cystic fibrosis transmembrane conductance regulator; BECN1; Cystic fibrosis; Ubiquitin; Cell biology; Microbiology; Burkholderia; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000688763,0.0001534988,0.0003359886,0.00002713667,0.000106402,0.00001921435,0.0003867727,0.0001102928,0.0001051694],"category_scores_gemma":[0.001474609,0.00006503372,0.0002266843,0.0002043602,0.0002196264,0.00008161399,0.0001658112,0.0004641344,0.000002227096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009466706,"about_ca_system_score_gemma":0.00008247533,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003280747,"about_ca_topic_score_gemma":9.721916e-7,"domain_scores_codex":[0.9984016,0.0001212936,0.0005586441,0.000137964,0.0004906838,0.0002898447],"domain_scores_gemma":[0.9982824,0.0005249525,0.000559203,0.0002683377,0.0002242518,0.0001408538],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003524981,0.00008998381,0.004952709,0.00006460976,0.00007449107,0.00000784963,0.0001862586,0.00002577792,0.9928526,0.000004653933,0.0001413254,0.001247219],"study_design_scores_gemma":[0.0004070388,0.0001840556,0.09447484,0.0001892525,0.00005981349,0.00008805434,0.000641147,0.00009729531,0.9035162,0.00004911772,0.0002266504,0.00006657763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955786,0.002841526,0.0001625933,0.0008682221,0.0001503305,0.000196878,0.00005891037,0.000008307546,0.0001346535],"genre_scores_gemma":[0.9978447,0.0001086956,0.001273044,0.0001051355,0.000592525,0.00000685347,0.000008525502,0.00001138948,0.00004912404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08952213,"threshold_uncertainty_score":0.2651998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02196473465395366,"score_gpt":0.2835881831362002,"score_spread":0.2616234484822466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}