{"id":"W2022894714","doi":"10.1074/jbc.m112.411728","title":"Depletion of the Ubiquitin-binding Adaptor Molecule SQSTM1/p62 from Macrophages Harboring cftr ΔF508 Mutation Improves the Delivery of Burkholderia cenocepacia to the Autophagic Machinery","year":2012,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Cystic Fibrosis Canada","keywords":"Burkholderia cenocepacia; Autophagy; Autophagosome; Biology; Sequestosome 1; Lysosome; Cystic fibrosis transmembrane conductance regulator; BECN1; Cystic fibrosis; Ubiquitin; Cell biology; Microbiology; Burkholderia; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001852814,0.0002960751,0.0003960266,0.0002419999,0.0001485777,0.0002672845,0.0002061564,0.0003965527,0.001003662],"category_scores_gemma":[0.0001152919,0.0001711309,0.0002141839,0.0001184929,0.0001685455,0.000287526,0.0002402046,0.0006576765,0.0003209417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000144992,"about_ca_system_score_gemma":0.0002263651,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005560655,"about_ca_topic_score_gemma":0.0005625397,"domain_scores_codex":[0.99983,0.0000249737,0.00002414779,0.00002650053,0.00003776333,0.00005650267],"domain_scores_gemma":[0.9998654,0.00001591945,0.00002709146,0.0000135113,0.00002113813,0.00005697451],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000224703,0.0000721163,0.00007224916,0.00002594041,0.000003501381,0.00003243034,0.000009754381,0.00003232514,0.9986964,0.00003071972,0.00005062662,0.0007493552],"study_design_scores_gemma":[0.0000433582,0.001115076,0.002516819,0.000009740521,0.0000165268,0.0001625526,0.00003314135,0.0007438214,0.9937494,0.00005238209,0.001551079,0.000006184848],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958522,0.001358146,0.001153011,0.0001648934,0.00005894486,0.00002180053,0.0002116042,0.0001203656,0.001058958],"genre_scores_gemma":[0.9961786,0.0006064859,0.001040619,0.00009219129,0.00001385523,0.00002575524,0.0003479663,0.00001802439,0.001676486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001003662,"threshold_uncertainty_score":0.00335753,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02196473465395366,"score_gpt":0.2835881831362002,"score_spread":0.2616234484822466,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}