{"id":"W2022895457","doi":"10.3851/imp1953","title":"A Case of a Potential Drug Interaction between Clobazam and Etravirine-Based Antiretroviral Therapy","year":2011,"lang":"en","type":"article","venue":"Antiviral Therapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Maple Leaf Medical Clinic; St. Michael's Hospital","funders":"","keywords":"Etravirine; Clobazam; Pharmacology; CYP3A4; CYP2C19; Metabolite; Reverse-transcriptase inhibitor; Drug; Active metabolite; Drug interaction; Pharmacokinetics; Cytochrome P450; Medicine; Internal medicine; Viral load; Antiretroviral therapy; Human immunodeficiency virus (HIV); Metabolism; Virology; Epilepsy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001747218,0.0002402498,0.0004069866,0.0001956286,0.00007988147,0.00001521294,0.00005873154,0.00008033028,0.0001085556],"category_scores_gemma":[0.000005340902,0.0001802992,0.0001473584,0.000191461,0.0001274408,0.0001578854,0.00001618597,0.0001537002,0.00001632419],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002463968,"about_ca_system_score_gemma":0.00006461488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002841426,"about_ca_topic_score_gemma":0.000009852297,"domain_scores_codex":[0.9989042,0.00008095743,0.0003145757,0.0002893172,0.000172304,0.0002385939],"domain_scores_gemma":[0.9994602,0.00003664592,0.0001346756,0.000219738,0.00006794443,0.0000807572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002402545,0.0008966563,0.7319782,0.00003528755,0.0005382748,0.001834877,0.002888054,1.042327e-7,0.01385574,0.0000805427,0.0003327578,0.2451569],"study_design_scores_gemma":[0.02280661,0.00403619,0.3954391,0.0002334451,0.0002501171,0.0008643242,0.0009491984,0.0002070045,0.5708918,0.0002970285,0.003296294,0.0007289525],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997472,0.0003757445,0.0001276843,0.0002646949,0.0001073959,0.0004662548,0.00001437138,0.00006269669,0.001109098],"genre_scores_gemma":[0.9972072,0.0004954256,0.001200516,0.0001258237,0.0001037395,0.0000150496,0.00003704379,0.00003048372,0.0007846893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.557036,"threshold_uncertainty_score":0.735239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04388811819660556,"score_gpt":0.2934531332387544,"score_spread":0.2495650150421488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}