{"id":"W2022895457","doi":"10.3851/imp1953","title":"A Case of a Potential Drug Interaction between Clobazam and Etravirine-Based Antiretroviral Therapy","year":2011,"lang":"en","type":"article","venue":"Antiviral Therapy","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Maple Leaf Medical Clinic; St. Michael's Hospital","funders":"","keywords":"Etravirine; Clobazam; Pharmacology; CYP3A4; CYP2C19; Metabolite; Reverse-transcriptase inhibitor; Drug; Active metabolite; Drug interaction; Pharmacokinetics; Cytochrome P450; Medicine; Internal medicine; Viral load; Antiretroviral therapy; Human immunodeficiency virus (HIV); Metabolism; Virology; Epilepsy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007945487,0.002518998,0.001634163,0.0043304,0.004664259,0.002014763,0.002631794,0.01320253,0.004705754],"category_scores_gemma":[0.006593394,0.001653526,0.00215295,0.002473307,0.002789774,0.003980128,0.002946045,0.009007025,0.001342304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003811571,"about_ca_system_score_gemma":0.001836592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006551432,"about_ca_topic_score_gemma":0.009069087,"domain_scores_codex":[0.9980924,0.0003506533,0.0001787097,0.0004387951,0.0003106773,0.0006288259],"domain_scores_gemma":[0.9960665,0.001569762,0.0006090344,0.0003059242,0.0002601867,0.001188698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00003657026,0.00005517355,0.001362101,0.00001353388,0.00000792368,0.9970862,0.0001253337,0.00004865363,0.0002195273,0.0002264397,0.0002061061,0.0006124735],"study_design_scores_gemma":[0.00002199933,0.00008046851,0.000938707,0.00001340205,0.00001460655,0.9973202,0.00008898894,0.0003409987,0.0002785288,0.0002519667,0.0006403764,0.000009732472],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8731184,0.01116153,0.01314973,0.03842524,0.002408192,0.0007135793,0.0005970167,0.0005217808,0.05990453],"genre_scores_gemma":[0.9817365,0.002010867,0.003503121,0.005832732,0.001606728,0.00006359904,0.0001420915,0.00005297631,0.005051397],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01320253,"threshold_uncertainty_score":0.02765501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04388811819660556,"score_gpt":0.2934531332387544,"score_spread":0.2495650150421488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}