{"id":"W2022901467","doi":"10.4161/hv.27657","title":"Screening vaccine formulations for biological activity using fresh human whole blood","year":2014,"lang":"en","type":"article","venue":"Human Vaccines & Immunotherapeutics","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Disability Prevention and Rehabilitation","funders":"","keywords":"Adjuvant; Immune system; Antigen; Monoclonal antibody; Immunology; Whole blood; Vaccine adjuvant; Medicine; Computational biology; Antibody; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007247818,0.0003772609,0.0005914588,0.0001552897,0.001059928,0.00006335429,0.0004023074,0.0005361201,0.000635396],"category_scores_gemma":[0.0000677202,0.0003023071,0.0003181399,0.0001982581,0.0001001288,0.0001204565,0.0001271857,0.0003920924,0.00001519347],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002816449,"about_ca_system_score_gemma":0.0000163744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005711876,"about_ca_topic_score_gemma":0.00005681573,"domain_scores_codex":[0.9979724,0.0003227936,0.0005297024,0.0004851422,0.00004965298,0.0006402613],"domain_scores_gemma":[0.9986081,0.0003834386,0.0002583497,0.0005611411,0.0001489152,0.00004009411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001487757,0.0003187033,0.007259821,0.00002100349,0.0004709403,3.704592e-7,0.00006119614,0.00001124644,0.9778965,0.00502768,0.0002475152,0.008536244],"study_design_scores_gemma":[0.01756603,0.003323854,0.1710934,0.0001873839,0.001697841,0.00009923921,0.0001346667,0.002109791,0.5224394,0.01690292,0.2624183,0.002027161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9094346,0.001428723,0.08724122,0.0004077283,0.0003258992,0.0005995056,0.0000665743,0.0001948214,0.0003008946],"genre_scores_gemma":[0.9869667,0.00001887588,0.01083859,0.0006860347,0.000222859,0.00002179302,0.0001002084,0.00005574008,0.001089225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4554572,"threshold_uncertainty_score":0.9999429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1014164351121218,"score_gpt":0.359725697494699,"score_spread":0.2583092623825772,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}