{"id":"W2022929720","doi":"10.1161/circulationaha.111.039644","title":"Proximal Cerebral Arteries Develop Myogenic Responsiveness in Heart Failure via Tumor Necrosis Factor-α–Dependent Activation of Sphingosine-1-Phosphate Signaling","year":2012,"lang":"en","type":"article","venue":"Circulation","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":72,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Centre for Phenogenomics; Toronto General Hospital","funders":"Canadian Institutes of Health Research","keywords":"Medicine; Heart failure; Cardiology; Internal medicine; Cerebral blood flow; Tumor necrosis factor alpha; Sphingosine; Myocardial infarction; Endocrinology; Anesthesia; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003546784,0.0001695921,0.0002143144,0.0001120333,0.00007701731,0.0000256419,0.00009435594,0.0001328377,0.00003008181],"category_scores_gemma":[0.0002006499,0.000179673,0.00007181297,0.0002423276,0.00003982846,0.00005525643,0.00004973417,0.00009046073,0.000003375604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003876007,"about_ca_system_score_gemma":0.00009663895,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000562289,"about_ca_topic_score_gemma":0.00001068545,"domain_scores_codex":[0.9987611,0.0001067644,0.0003689654,0.0002622156,0.0001967866,0.0003041507],"domain_scores_gemma":[0.9993098,0.00002249469,0.0002350867,0.0002063865,0.0001581172,0.00006812759],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001137957,0.00003617614,0.2685267,0.00003115035,0.00001369599,1.843913e-7,0.0003312647,0.0006046279,0.7299889,0.00004133478,0.000006712563,0.0003054637],"study_design_scores_gemma":[0.0003597577,0.00001453128,0.3813642,0.00002894659,0.000009172881,0.000005763183,0.0000769508,0.0001237142,0.6176004,0.0000326453,0.0002495645,0.0001343915],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9909976,0.0002573399,0.008203981,0.00005773898,0.0001867812,0.0002661285,0.000008324498,0.00001424363,0.000007884312],"genre_scores_gemma":[0.9980721,0.000003162519,0.001398953,0.00008495319,0.0002567641,0.00002722481,0.0001216614,0.00002684244,0.000008273273],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1128375,"threshold_uncertainty_score":0.7326853,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01414053428498008,"score_gpt":0.2416367670442549,"score_spread":0.2274962327592748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}