{"id":"W2022956911","doi":"10.1038/ncb3021","title":"Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state","year":2014,"lang":"en","type":"article","venue":"Nature Cell Biology","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":190,"is_retracted":false,"has_abstract":false,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University Health Network; Ontario Institute for Cancer Research","funders":"Japan Society for the Promotion of Science; Canadian Institutes of Health Research; Ontario Institute for Cancer Research","keywords":"Cell biology; Microvesicles; Cancer cell; Biology; Stromal cell; Exosome; Extracellular matrix; RHOA; Cell migration; Tumor microenvironment; Cancer research; Motility; Cancer-Associated Fibroblasts; Cell; Cancer; Signal transduction; microRNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003342359,0.0001541013,0.0001486466,0.00001635251,0.0001099437,0.000005211219,0.0007418355,0.0003847095,0.00001008169],"category_scores_gemma":[0.00005794121,0.00007794034,0.0002558771,0.0001033745,0.0003816537,0.000001359935,0.0002609992,0.0002173424,0.000002426428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001110126,"about_ca_system_score_gemma":0.00007843644,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001142937,"about_ca_topic_score_gemma":0.000008132232,"domain_scores_codex":[0.9989173,0.0001891558,0.0002445027,0.0003021781,0.0001092818,0.0002375274],"domain_scores_gemma":[0.9985603,0.00009232073,0.0002650036,0.0008779377,0.0001694786,0.00003493251],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009114582,0.00009120346,0.001274862,0.00004246767,0.00002544508,1.120352e-7,0.00006547289,0.0001938698,0.9942325,0.00009475977,0.003538805,0.0003494039],"study_design_scores_gemma":[0.0004607963,0.0001597824,0.002937923,0.000005383107,0.00005217983,0.000001299405,0.00003422289,0.0002749605,0.9407416,0.0002721637,0.05496426,0.00009542018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889048,0.007078161,0.00156505,0.0004137403,0.0007250556,0.0004783811,0.0003088757,0.00000417992,0.0005218078],"genre_scores_gemma":[0.9967793,0.0001579003,0.0001773282,0.001961267,0.0001354961,0.00001800534,0.00006462604,0.00001880261,0.0006873283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05349084,"threshold_uncertainty_score":0.3178315,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003718477970684793,"score_gpt":0.2259518761636499,"score_spread":0.2222333981929651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}