{"id":"W2022959322","doi":"10.1242/dev.043471","title":"FGF signal-dependent segregation of primitive endoderm and epiblast in the mouse blastocyst","year":2010,"lang":"en","type":"article","venue":"Development","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":599,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Vetenskapsrådet","keywords":"Epiblast; Biology; Blastocyst; Inner cell mass; Cell biology; Nanog Homeobox Protein; Embryonic stem cell; Progenitor cell; Cell fate determination; Homeobox protein NANOG; Genetics; Endoderm; Stem cell; Embryogenesis; Transcription factor; Embryo; Gene; Gastrulation; SOX2; Induced pluripotent stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003916032,0.00008785563,0.00008019419,0.00005391876,0.00004417113,0.00001444974,0.0001536142,0.00007532626,0.00001513125],"category_scores_gemma":[0.00003947881,0.00006601825,0.00001653197,0.00006040797,0.00006589512,0.000003097577,0.0001101959,0.0001293532,0.000006527739],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000115104,"about_ca_system_score_gemma":0.0001138756,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001399489,"about_ca_topic_score_gemma":0.0003263516,"domain_scores_codex":[0.9991877,0.00005537779,0.0001742302,0.0002002439,0.0002214537,0.0001610081],"domain_scores_gemma":[0.9996765,0.00002225076,0.00005237988,0.0001503079,0.00006234876,0.00003623137],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003608202,0.0000656604,0.003552073,0.00001882054,0.00001645215,0.000003958129,0.0006087081,0.0000110807,0.9898621,0.00005456274,0.00008769527,0.005682799],"study_design_scores_gemma":[0.0004232673,0.00005374665,0.04136148,0.000007215898,0.000002068584,0.00001454387,0.0002122091,0.00003411476,0.953208,0.00001447061,0.004583473,0.00008538039],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981223,0.00004401475,0.0003182466,0.0001042672,0.00002291869,0.0002871904,0.000005971669,0.000002611403,0.001092534],"genre_scores_gemma":[0.9982806,0.00003598388,0.001000265,0.00005437486,0.00001850024,0.00004624341,0.00005315008,0.000007765647,0.000503064],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03780941,"threshold_uncertainty_score":0.2692146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009835357759033285,"score_gpt":0.2414548609977111,"score_spread":0.2316195032386778,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}