{"id":"W2022980912","doi":"10.1038/mp.2015.49","title":"p75NTR ectodomain is a physiological neuroprotective molecule against amyloid-beta toxicity in the brain of Alzheimer’s disease","year":2015,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; Kunming Medical University; Chongqing Science and Technology Commission; National Institute of Mental Health; China Postdoctoral Science Foundation; York University; National Natural Science Foundation of China; University of South Australia; Chongqing Postdoctoral Science Foundation","keywords":"Ectodomain; Neuroprotection; Neurodegeneration; Neurotrophin; Neuroscience; Neurotrophic factors; Amyloid precursor protein; ADAM10; Alzheimer's disease; Amyloid beta; Chemistry; Receptor; Cell biology; Biology; Disintegrin; Internal medicine; Medicine; Biochemistry; Metalloproteinase; Disease; Matrix metalloproteinase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006329411,0.0002589305,0.0001895449,0.0001403085,0.0001384338,0.0002192986,0.0001173991,0.0001543091,0.0005240488],"category_scores_gemma":[0.0000522745,0.00004098648,0.000108554,0.0001053841,0.0002258899,0.0001504451,0.00009017724,0.0002803708,0.0001804306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002329521,"about_ca_system_score_gemma":0.0002228944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001043171,"about_ca_topic_score_gemma":0.0007563315,"domain_scores_codex":[0.999961,0.00000417931,0.000003131917,0.000007554404,0.00001562214,0.000008566551],"domain_scores_gemma":[0.9999832,0.000001659646,0.000005385854,0.000001455404,0.000002889476,0.000005478292],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002082045,0.00003314988,0.0002585558,0.0001351608,0.000009166914,0.0002824717,0.00002200757,0.00007040173,0.9826589,0.0003674353,0.0001662362,0.01578842],"study_design_scores_gemma":[0.00006455709,0.001083262,0.02430363,0.00003167269,0.00007841952,0.002802867,0.00007781289,0.0005435224,0.9515243,0.000652085,0.01882056,0.00001728006],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9179704,0.07116462,0.004304294,0.0005468974,0.0001734963,0.00003639897,0.0003723695,0.0001493907,0.005282259],"genre_scores_gemma":[0.9786673,0.01680358,0.001703564,0.0001085878,0.00005530645,0.0000142713,0.0001909644,0.000005814749,0.002450694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001043171,"threshold_uncertainty_score":0.002074242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0428841296845581,"score_gpt":0.2925249451740053,"score_spread":0.2496408154894472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}