{"id":"W2022980912","doi":"10.1038/mp.2015.49","title":"p75NTR ectodomain is a physiological neuroprotective molecule against amyloid-beta toxicity in the brain of Alzheimer’s disease","year":2015,"lang":"en","type":"article","venue":"Molecular Psychiatry","topic":"Nerve injury and regeneration","field":"Neuroscience","cited_by":113,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Health and Medical Research Council; Kunming Medical University; Chongqing Science and Technology Commission; National Institute of Mental Health; China Postdoctoral Science Foundation; York University; National Natural Science Foundation of China; University of South Australia; Chongqing Postdoctoral Science Foundation","keywords":"Ectodomain; Neuroprotection; Neurodegeneration; Neurotrophin; Neuroscience; Neurotrophic factors; Amyloid precursor protein; ADAM10; Alzheimer's disease; Amyloid beta; Chemistry; Receptor; Cell biology; Biology; Disintegrin; Internal medicine; Medicine; Biochemistry; Metalloproteinase; Disease; Matrix metalloproteinase","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003930073,0.0002242619,0.0002216937,0.00009366986,0.0001041506,0.00003909,0.0004844825,0.00007933124,0.00001092241],"category_scores_gemma":[0.000300878,0.000156784,0.0001864416,0.000563045,0.0002121697,0.0001010775,0.00009625318,0.0003137859,0.00002379163],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001889961,"about_ca_system_score_gemma":0.000144406,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001581002,"about_ca_topic_score_gemma":0.000005540454,"domain_scores_codex":[0.9971591,0.001169415,0.0003290068,0.0005642837,0.0004742672,0.0003038856],"domain_scores_gemma":[0.9990175,0.00005211815,0.0001531208,0.0005857186,0.00004026944,0.0001512755],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001583417,0.0004989762,0.0002218799,0.00001217867,0.000009393092,0.00009960432,0.0003765781,0.000996494,0.989473,0.005552627,0.002374992,0.0002259493],"study_design_scores_gemma":[0.000970329,0.0004001503,0.006238039,0.00002835937,0.00003357237,0.000008274431,0.00015964,0.001506851,0.9827783,0.007413736,0.0001655318,0.0002972722],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881083,0.000374853,0.000760237,0.008659781,0.0003294603,0.0006426891,0.00003452775,0.00003850757,0.001051593],"genre_scores_gemma":[0.9825889,0.000004995809,0.0002455945,0.01695613,0.00009814289,0.00006080616,0.000006878663,0.00002163359,0.00001689444],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008296345,"threshold_uncertainty_score":0.6393465,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0428841296845581,"score_gpt":0.2925249451740053,"score_spread":0.2496408154894472,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}