{"id":"W2023005572","doi":"10.1007/s00702-011-0646-1","title":"Genotype-, aging-dependent abnormal caspase activity in Huntington disease blood cells","year":2011,"lang":"en","type":"article","venue":"Journal of Neural Transmission","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"European Huntington's Disease Network","keywords":"Huntingtin; Huntington's disease; Biology; Genotype; Caspase; Apoptosis; Mutation; Caspase 3; Molecular biology; Genetics; Programmed cell death; Internal medicine; Gene; Disease; Medicine; Mutant","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001993742,0.0002378827,0.0002683125,0.0002421701,0.0001079905,0.00004174758,0.0003916955,0.00004821561,0.0002202342],"category_scores_gemma":[0.0001141901,0.0001905594,0.0002071203,0.0002378256,0.00007065333,0.0004297099,0.00004336515,0.0004345525,0.00001008707],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002556702,"about_ca_system_score_gemma":0.0001213645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001927741,"about_ca_topic_score_gemma":0.000003487046,"domain_scores_codex":[0.997793,0.0004179713,0.0004804245,0.0003482112,0.0005883347,0.0003721113],"domain_scores_gemma":[0.9987691,0.0001025363,0.000315251,0.0002148386,0.00007195553,0.0005263247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007092352,0.0008308134,0.00426003,0.00004515559,0.000003994393,0.001118172,0.000350079,0.0006511151,0.9870476,0.000007706518,0.00002021178,0.004955848],"study_design_scores_gemma":[0.001246293,0.0003086672,0.06491721,0.00006504708,0.00006773614,0.00005843188,0.00001446685,0.0004672466,0.932514,0.0001080552,0.00005049334,0.0001824098],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9985472,0.0001088483,0.0003088468,0.0002406141,0.0003754944,0.000182305,0.000009867415,0.00001907472,0.0002077557],"genre_scores_gemma":[0.9990144,0.0001744652,0.0002588209,0.0003131156,0.0001029326,0.000002565502,2.367593e-7,0.00002939381,0.0001040921],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06065718,"threshold_uncertainty_score":0.7770787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0420354907692598,"score_gpt":0.2637593441961977,"score_spread":0.2217238534269379,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}