{"id":"W2023034253","doi":"10.1038/ki.2013.354","title":"Exome sequencing and in vitro studies identified podocalyxin as a candidate gene for focal and segmental glomerulosclerosis","year":2013,"lang":"en","type":"article","venue":"Kidney International","topic":"Renal Diseases and Glomerulopathies","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research","keywords":"Slit diaphragm; Podocyte; Exome sequencing; Biology; Focal segmental glomerulosclerosis; Exome; Genetics; Transmembrane protein; Gene; Podocalyxin; Mutation; Cell biology; Glomerulonephritis; Proteinuria; Kidney","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001833292,0.0004247228,0.0003660123,0.0006500293,0.0003993802,0.0004272621,0.0002294417,0.0007390002,0.001543219],"category_scores_gemma":[0.0006232353,0.000105646,0.0005233103,0.0003418723,0.000241176,0.0001772379,0.0002625783,0.0005554633,0.0002629077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003219334,"about_ca_system_score_gemma":0.0001996943,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001358189,"about_ca_topic_score_gemma":0.001491554,"domain_scores_codex":[0.9998747,0.00001406275,0.00001503163,0.0000392096,0.00003243032,0.00002459656],"domain_scores_gemma":[0.9997249,0.0001371959,0.00004082305,0.00001753955,0.0000340812,0.00004534452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007272119,0.0001252528,0.04280045,0.0001278767,0.0001587133,0.02874172,0.00020932,0.0006698156,0.9140182,0.0009421785,0.0005817098,0.01089742],"study_design_scores_gemma":[0.0001139992,0.0004300158,0.3539118,0.00008326844,0.0006526179,0.05920041,0.0005092139,0.009150265,0.55974,0.001992898,0.01415425,0.00006124834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926958,0.0006015358,0.003660712,0.0004238534,0.00005849318,0.00002575513,0.001254542,0.00004197945,0.001237397],"genre_scores_gemma":[0.9942887,0.0003281588,0.002793656,0.0001905501,0.00002214414,0.00001262464,0.00117852,0.00001468867,0.00117097],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001543219,"threshold_uncertainty_score":0.005162597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02551816205885834,"score_gpt":0.3059816364791534,"score_spread":0.2804634744202951,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}