{"id":"W2023058650","doi":"10.1016/j.ymgme.2006.09.011","title":"Identification of a canine model of pyruvate dehydrogenase phosphatase 1 deficiency","year":2006,"lang":"en","type":"article","venue":"Molecular Genetics and Metabolism","topic":"Metabolism and Genetic Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research","keywords":"Pyruvate dehydrogenase complex; Pyruvate dehydrogenase phosphatase; Biology; Exercise intolerance; Mutation; Glycolysis; Pyruvate dehydrogenase kinase; Carnitine; Genetics; Endocrinology; Internal medicine; Biochemistry; Enzyme; Medicine; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001006784,0.001423348,0.001173862,0.002411754,0.001319391,0.0009038355,0.001397773,0.002625008,0.003195866],"category_scores_gemma":[0.001698861,0.0006481907,0.0007619043,0.0006910948,0.002256618,0.001345398,0.0009687966,0.00250388,0.0006601435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00180645,"about_ca_system_score_gemma":0.0009818878,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001621196,"about_ca_topic_score_gemma":0.001855348,"domain_scores_codex":[0.9990935,0.0002208283,0.00009537598,0.0002226462,0.0001869092,0.0001807072],"domain_scores_gemma":[0.9986603,0.0005558225,0.000231816,0.0001327041,0.00008708341,0.0003323493],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.008199347,0.003409085,0.004286864,0.0004676492,0.0001687055,0.02369458,0.0003913367,0.002540187,0.9210335,0.0235798,0.004525616,0.007703261],"study_design_scores_gemma":[0.003892988,0.01592838,0.02043683,0.0002133333,0.0007407335,0.1194918,0.0008031595,0.03122411,0.7566024,0.008697993,0.04164711,0.0003211791],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798633,0.001657543,0.008346258,0.002606771,0.0005179982,0.0005959283,0.001851666,0.0003122393,0.004248237],"genre_scores_gemma":[0.9891066,0.0007438063,0.005365768,0.0002719751,0.0001005141,0.0002673237,0.00130777,0.0000790123,0.002757321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003195866,"threshold_uncertainty_score":0.01310682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004589766701920188,"score_gpt":0.2119935825768416,"score_spread":0.2074038158749214,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}