{"id":"W2023067893","doi":"10.1021/jm0610548","title":"Structure−Activity Relationships of a Series of Analogs of the Endozepine Octadecaneuropeptide (ODN<sub>11</sub><sub>-</sub><sub>18</sub>) on Neurosteroid Biosynthesis by Hypothalamic Explants","year":2007,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Stress Responses and Cortisol","field":"Neuroscience","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Neuroactive steroid; Chemistry; Biosynthesis; Dehydroepiandrosterone; Steroid; Biological activity; Stereochemistry; Steroid hormone; Amino acid; Internal medicine; Hormone; Endocrinology; Biochemistry; In vitro; Receptor; Gene; Biology; Androgen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007167329,0.0002342021,0.000163664,0.0001094979,0.00006022181,0.0001471433,0.0000964236,0.0001376771,0.0009942927],"category_scores_gemma":[0.0001337671,0.0000799015,0.0001413879,0.00008329699,0.0001406305,0.00010068,0.00007127219,0.0002719575,0.0001986877],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001430051,"about_ca_system_score_gemma":0.0001484538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000497677,"about_ca_topic_score_gemma":0.0008231261,"domain_scores_codex":[0.9999608,0.000006222836,0.000004870647,0.000007001715,0.00001267641,0.000008476407],"domain_scores_gemma":[0.9998949,0.0000243318,0.00002805733,0.000007525044,0.00001235289,0.00003287168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001707027,0.00002850482,0.0001657445,0.00002307829,0.000003916388,0.00003103208,0.000006721144,0.0001052002,0.9982426,0.00001679142,0.000005353731,0.00120045],"study_design_scores_gemma":[0.0000326229,0.001534063,0.004127741,0.000004729575,0.00001836523,0.0001873537,0.00001788179,0.0002860099,0.9923502,0.00001709569,0.001419029,0.000004853439],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976005,0.001077555,0.0003622018,0.00001379069,0.000007195391,0.00002397444,0.0001482711,0.000005052216,0.0007614104],"genre_scores_gemma":[0.9947538,0.001780348,0.00181682,0.00004132628,0.000007262183,0.00002680582,0.000551317,0.000004789923,0.001017552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009942927,"threshold_uncertainty_score":0.003326237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02828010202029946,"score_gpt":0.2421295313559532,"score_spread":0.2138494293356537,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}