{"id":"W2023088935","doi":"10.1016/j.clinthera.2006.05.016","title":"Relative bioavailability of the fentanyl effervescent buccal tablet (FEBT) 1080 pg versus Oral transmucosal fentanyl citrate 1600 pg and dose proportionality of FEBT 270 to 1300 μg: A single-dose, randomized, open-label, three-period study in healthy adult volunteers","year":2006,"lang":"en","type":"article","venue":"Clinical Therapeutics","topic":"Pain Management and Opioid Use","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"Carbon Engineering (Canada)","funders":"","keywords":"Medicine; Fentanyl; Buccal administration; Bioavailability; Anesthesia; Naltrexone; Crossover study; Placebo; Pharmacology; Opioid; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00567793,0.0004343805,0.001852984,0.0001206588,0.0001391106,0.00005446688,0.0005388583,0.0002658011,0.00006620774],"category_scores_gemma":[0.0008518498,0.0002975386,0.0003250789,0.0007877679,0.001268627,0.0001665677,0.0002629209,0.0007408425,0.000005551678],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002323898,"about_ca_system_score_gemma":0.0003718113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008543778,"about_ca_topic_score_gemma":0.002990136,"domain_scores_codex":[0.9934736,0.001786222,0.002603819,0.0008240489,0.0007868002,0.0005254482],"domain_scores_gemma":[0.9965375,0.001358012,0.0006025444,0.0008630504,0.0003806436,0.000258247],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.2941754,0.01440734,0.684692,0.0002676157,0.0007897073,0.00001845611,0.001052472,0.0000165605,0.000532984,0.001453108,0.00009788912,0.002496375],"study_design_scores_gemma":[0.319241,0.006868623,0.6671399,0.0003113404,0.001039395,0.000001573147,0.00110774,0.001958494,0.0001580906,0.00148005,0.0003168894,0.0003769411],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985213,0.0004228258,0.0003516782,0.005150656,0.0005523873,0.007944535,0.00005864969,0.00003658165,0.0002697066],"genre_scores_gemma":[0.996505,0.0001467688,0.001612674,0.001327585,0.000099406,0.00009869109,0.00002892303,0.00004171086,0.0001392162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02506554,"threshold_uncertainty_score":0.9999477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1331273563298829,"score_gpt":0.4054887315207883,"score_spread":0.2723613751909054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}