{"id":"W2023088935","doi":"10.1016/j.clinthera.2006.05.016","title":"Relative bioavailability of the fentanyl effervescent buccal tablet (FEBT) 1080 pg versus Oral transmucosal fentanyl citrate 1600 pg and dose proportionality of FEBT 270 to 1300 μg: A single-dose, randomized, open-label, three-period study in healthy adult volunteers","year":2006,"lang":"en","type":"article","venue":"Clinical Therapeutics","topic":"Pain Management and Opioid Use","field":"Medicine","cited_by":52,"is_retracted":false,"has_abstract":false,"ca_institutions":"Carbon Engineering (Canada)","funders":"","keywords":"Medicine; Fentanyl; Buccal administration; Bioavailability; Anesthesia; Naltrexone; Crossover study; Placebo; Pharmacology; Opioid; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003121993,0.001797732,0.00397207,0.0008013093,0.0007347115,0.001108062,0.001369951,0.002716134,0.004671102],"category_scores_gemma":[0.005264859,0.001904151,0.001591874,0.0005829239,0.003021429,0.00219176,0.0005489534,0.003354679,0.001103244],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007666569,"about_ca_system_score_gemma":0.001039755,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001402299,"about_ca_topic_score_gemma":0.001450701,"domain_scores_codex":[0.9979784,0.0009185462,0.0001316492,0.000524698,0.000209416,0.0002372538],"domain_scores_gemma":[0.9967594,0.001318189,0.0006677018,0.000407236,0.0002190927,0.0006284746],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.977015,0.008846346,0.0003430845,0.0001457188,0.0001753531,0.00002415255,0.0000814513,0.0001466698,0.007164236,0.00004166458,0.0001226233,0.005893621],"study_design_scores_gemma":[0.3932858,0.5920132,0.007102169,0.00001393791,0.0006843223,0.00006864074,0.00005889204,0.001034349,0.005176484,0.000133261,0.0003722876,0.00005665737],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966177,0.0007767263,0.0006409698,0.00008652556,0.0001499939,0.001038793,0.0002291249,0.00006743342,0.000392629],"genre_scores_gemma":[0.9938715,0.0008035669,0.001666572,0.0002441034,0.0003828543,0.001082232,0.0003069747,0.00004418431,0.001598106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004671102,"threshold_uncertainty_score":0.01651084,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1331273563298829,"score_gpt":0.4054887315207883,"score_spread":0.2723613751909054,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}