{"id":"W2023142724","doi":"10.3389/fcimb.2013.00003","title":"Recognition of lipid A variants by the TLR4-MD-2 receptor complex","year":2013,"lang":"en","type":"review","venue":"Frontiers in Cellular and Infection Microbiology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":271,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Lipid A; TLR4; Biology; Receptor; Lipopolysaccharide; Innate immune system; Immune system; Pattern recognition receptor; Toll-like receptor; Signal transduction; Cell biology; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006200508,0.0004176783,0.001401897,0.0004166834,0.0001709695,0.00002001562,0.0002177572,0.001173232,0.0009043331],"category_scores_gemma":[0.00009059127,0.0002984221,0.0002904103,0.0003028593,0.0004873689,0.0001172116,0.0001060981,0.0007028488,0.000432592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001005112,"about_ca_system_score_gemma":0.00009342571,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001770263,"about_ca_topic_score_gemma":0.000003816,"domain_scores_codex":[0.996492,0.001686024,0.0009813047,0.00043995,0.00001819274,0.0003824921],"domain_scores_gemma":[0.9987067,0.0001930227,0.0006760184,0.0003240138,0.00008301836,0.00001722097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005042907,0.00009888399,0.00003655871,0.001178402,0.000375772,4.37729e-7,0.00009410498,1.004734e-7,0.1449724,0.00001336843,0.2046543,0.6485252],"study_design_scores_gemma":[0.0006497957,0.0001729274,0.000006428817,0.0008160365,0.0002184456,0.000137304,0.00003642438,0.000001224659,0.008237067,0.00003417667,0.9893839,0.0003062324],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001640056,0.992441,0.001121784,0.00003149013,0.003138816,0.001099094,0.0001852675,0.00003185804,0.0003106164],"genre_scores_gemma":[0.0001219806,0.9929417,0.000150753,0.0000393894,0.0000690689,0.0001420678,0.00549555,0.00003468536,0.001004856],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7847297,"threshold_uncertainty_score":0.9999468,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02565766528270469,"score_gpt":0.2467829942720737,"score_spread":0.221125328989369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}