{"id":"W2023182330","doi":"10.1016/j.jalz.2012.05.1971","title":"O5‐01‐03: LDLR‐related protein 10 (LRP10) alters amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer's disease","year":2012,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Endosome; Amyloid precursor protein; Amyloid precursor protein secretase; Cell biology; Endocytic cycle; Golgi apparatus; Alpha secretase; Retromer; LDL receptor; Immunoprecipitation; P3 peptide; Biology; Chemistry; Intracellular; Receptor; Alzheimer's disease; Endocytosis; Biochemistry; Internal medicine; Medicine; Gene; Lipoprotein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000152924,0.0004503854,0.0003685331,0.000230669,0.0001886819,0.0003064654,0.0003357452,0.0006519411,0.0030038],"category_scores_gemma":[0.0001158646,0.0001875828,0.0003778934,0.0001826637,0.0004367791,0.0002742682,0.0002324334,0.0009191043,0.0008154817],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003472369,"about_ca_system_score_gemma":0.0003490983,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001603958,"about_ca_topic_score_gemma":0.001039286,"domain_scores_codex":[0.9998166,0.00002679492,0.00002377455,0.00003828937,0.00003052503,0.00006415139],"domain_scores_gemma":[0.9998678,0.00001619812,0.00002320078,0.00001211252,0.000008833824,0.000071799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009414202,0.0002616922,0.0002531782,0.00003668375,0.00001280806,0.0002585771,0.0000161612,0.00001932327,0.9969835,0.0000581028,0.00009817971,0.001060417],"study_design_scores_gemma":[0.0002467166,0.003503376,0.01383068,0.00001436196,0.00007580663,0.001481409,0.0001008871,0.0005813374,0.9754637,0.00007875353,0.00460752,0.00001532467],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975685,0.0006434263,0.0004575429,0.0001807424,0.00008119878,0.00002214814,0.0003273928,0.00005294863,0.0006659458],"genre_scores_gemma":[0.9940749,0.0006943553,0.0005928723,0.0002340093,0.00002064293,0.00005961682,0.0007686191,0.00003393671,0.003521007],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0030038,"threshold_uncertainty_score":0.01004875,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04897299749116503,"score_gpt":0.3291890848491657,"score_spread":0.2802160873580007,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}