{"id":"W2023209616","doi":"10.1021/jm801218k","title":"Design and Synthesis of Androgen Receptor Antagonists with Bulky Side Chains for Overcoming Antiandrogen Resistance","year":2009,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Queen's University; Institute for Research in Immunology and Cancer","funders":"","keywords":"Antiandrogen; Chemistry; Androgen receptor; Side chain; Androgen; Pharmacology; Chemical synthesis; Stereochemistry; Internal medicine; Prostate cancer; Biochemistry; In vitro; Hormone; Organic chemistry; Cancer; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001158346,0.000396496,0.0004639266,0.0001813958,0.0001073271,0.0002197264,0.0003326648,0.0002528729,0.001299967],"category_scores_gemma":[0.00008649527,0.0002229308,0.0002583163,0.0001409153,0.0001540725,0.0002641336,0.0001721303,0.0004666861,0.0006820802],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002256824,"about_ca_system_score_gemma":0.0002342497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002566673,"about_ca_topic_score_gemma":0.0008190353,"domain_scores_codex":[0.9999397,0.000009524048,0.000005862874,0.00001288579,0.00001455007,0.00001747507],"domain_scores_gemma":[0.9999454,0.000005138564,0.00001502603,0.000006906349,0.00001019821,0.00001728682],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001607663,0.00005722256,0.00004855026,0.0001065022,0.00001354566,0.00008543058,0.00001566675,0.0006416686,0.9892993,0.000320304,0.0001405759,0.009110374],"study_design_scores_gemma":[0.00033236,0.002455763,0.001111071,0.00002565568,0.00006874214,0.0003861975,0.00001958456,0.001633898,0.9719192,0.0002110106,0.02180135,0.00003509706],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9624786,0.008320911,0.02030093,0.0003365588,0.0001162646,0.0004866408,0.0006662844,0.0003274686,0.006966352],"genre_scores_gemma":[0.9618812,0.007928098,0.02250706,0.0002417827,0.0000531924,0.0002806596,0.0007517592,0.0000556823,0.006300654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001299967,"threshold_uncertainty_score":0.004348874,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006039851352754081,"score_gpt":0.2318201403333342,"score_spread":0.2257802889805801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}