{"id":"W2023209616","doi":"10.1021/jm801218k","title":"Design and Synthesis of Androgen Receptor Antagonists with Bulky Side Chains for Overcoming Antiandrogen Resistance","year":2009,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Queen's University; Institute for Research in Immunology and Cancer","funders":"","keywords":"Antiandrogen; Chemistry; Androgen receptor; Side chain; Androgen; Pharmacology; Chemical synthesis; Stereochemistry; Internal medicine; Prostate cancer; Biochemistry; In vitro; Hormone; Organic chemistry; Cancer; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004591251,0.0001563143,0.0003175735,0.0000278442,0.00005813007,0.000009312161,0.0001414503,0.0001742493,0.000003138821],"category_scores_gemma":[0.0001847058,0.0001155072,0.0000886659,0.00006074826,0.0001107606,0.000006662577,0.00001300997,0.0001453053,1.093596e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001699232,"about_ca_system_score_gemma":0.0001717737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":5.59384e-7,"about_ca_topic_score_gemma":1.492645e-7,"domain_scores_codex":[0.9990843,0.00002439538,0.0003340921,0.0001676902,0.0002020863,0.000187458],"domain_scores_gemma":[0.9990814,0.00008323351,0.0003896474,0.0001420374,0.0001573615,0.0001463722],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002202142,0.00007668161,0.0001837811,0.0001571513,0.0001411942,0.00003629384,0.00004359252,0.00002887249,0.9941122,0.000004142041,0.001112215,0.001901768],"study_design_scores_gemma":[0.001494243,0.0009050093,0.00006666996,0.0003894933,0.0001520006,0.0005611465,0.00008827328,0.00002892272,0.9947295,0.00002436782,0.001427645,0.0001327801],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872084,0.008264365,0.003654204,0.0004682574,0.00003620465,0.0001395328,0.00000830743,0.000003406828,0.0002173017],"genre_scores_gemma":[0.990628,0.001119576,0.007724413,0.00006269499,0.0002628038,0.00000292449,0.000006209866,0.00001601567,0.0001773712],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007144788,"threshold_uncertainty_score":0.4710248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006039851352754081,"score_gpt":0.2318201403333342,"score_spread":0.2257802889805801,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}