{"id":"W2023215532","doi":"10.4161/auto.5407","title":"HspB8 and Bag3: A new chaperone complex targeting misfolded proteins to macroautophagy","year":2008,"lang":"en","type":"review","venue":"Autophagy","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":233,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"Canadian Institutes of Health Research; Canada Research Chairs","keywords":"BAG3; Co-chaperone; WW domain; Biology; Chaperone (clinical); Cell biology; Autophagy; Protein folding; Heat shock protein; Hsp70; Biochemistry; Gene; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000290683,0.0007876685,0.001521848,0.0002600244,0.0002718437,0.00008496623,0.0007551668,0.0007541223,0.0002934643],"category_scores_gemma":[0.0004438588,0.0007239713,0.0003927115,0.0004227493,0.0001418438,0.000006866799,0.000983665,0.0005168957,0.0003398803],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009944791,"about_ca_system_score_gemma":0.001110123,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002309214,"about_ca_topic_score_gemma":0.00002640979,"domain_scores_codex":[0.9960402,0.0002578376,0.0008022121,0.001385515,0.0004631426,0.001051094],"domain_scores_gemma":[0.9979049,0.00004171828,0.0001898157,0.0009684858,0.000114565,0.0007805028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002428529,0.00007242036,8.478265e-7,0.002506013,0.0002024586,0.0001246444,0.00007100404,0.000001272773,0.02259668,0.00004897239,0.02098324,0.9533682],"study_design_scores_gemma":[0.0004353162,0.0004347441,0.00001301873,0.0007487249,0.00005180651,0.0002797414,0.000005342698,0.00001148223,0.004634941,0.00001218293,0.9926705,0.0007022504],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006737229,0.9943586,0.0005946142,0.0001097042,0.0001014357,0.003233183,0.00008377258,0.00007056257,0.0007744219],"genre_scores_gemma":[0.0001731975,0.9823383,0.006928503,0.0002559396,0.001000722,0.0005207162,0.0006696182,0.0002016245,0.007911379],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9716872,"threshold_uncertainty_score":0.9995211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05884697163149313,"score_gpt":0.3544047724719513,"score_spread":0.2955578008404581,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}