{"id":"W2023243427","doi":"10.1074/jbc.m202723200","title":"Threonine 308 within a Putative Casein Kinase 2 Site of the Cytoplasmic Tail of Leukotriene B4 Receptor (BLT1) Is Crucial for Ligand-induced, G-protein-coupled Receptor-specific Kinase 6-mediated Desensitization","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Desensitization (medicine); Receptor; Casein kinase 2; Homologous desensitization; Chemistry; Threonine; Ligand (biochemistry); Protein kinase A; G protein-coupled receptor kinase; Leukotriene receptor; Protein kinase C; Kinase; Biochemistry; G protein-coupled receptor; Cell biology; Biology; Mitogen-activated protein kinase kinase; Phosphorylation; Antagonist; Serine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005275764,0.0002843113,0.0005373796,0.00004030248,0.0001130739,0.00001995608,0.0002989859,0.0004976348,0.0003129959],"category_scores_gemma":[0.0006277087,0.0001897455,0.0004140139,0.0002518405,0.0001759375,0.00001267513,0.00009268189,0.0002933175,0.00000282829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005699949,"about_ca_system_score_gemma":0.00009983462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005078371,"about_ca_topic_score_gemma":7.889263e-7,"domain_scores_codex":[0.9980201,0.00009659286,0.0009632635,0.000345095,0.0002925337,0.0002824751],"domain_scores_gemma":[0.9975342,0.0000771837,0.001286009,0.0002630888,0.0006960081,0.0001434727],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007582072,0.0001799199,0.0001733545,0.00005679864,0.00009018397,0.000006077223,0.0001855394,0.00009241118,0.9974665,0.00001098522,0.0004979451,0.000482101],"study_design_scores_gemma":[0.001585698,0.0009189044,0.00004104738,0.0001049241,0.00003040443,0.0000424453,0.0003639776,0.0004100688,0.9950972,0.0000834679,0.001099665,0.000222174],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964647,0.001148394,0.001355476,0.000249871,0.0002507312,0.0003113021,0.0001849504,0.000006541542,0.00002807385],"genre_scores_gemma":[0.9962049,0.0004642418,0.00233396,0.0000817648,0.0006612814,0.00001290571,0.0001000375,0.00002530449,0.0001155675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002369254,"threshold_uncertainty_score":0.7737598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02774688687374655,"score_gpt":0.2353714860456715,"score_spread":0.207624599171925,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}