{"id":"W2023280521","doi":"10.1016/j.cbpc.2008.06.002","title":"The cannabinoid receptor agonist CP-55,940 and ethyl arachidonate interfere with [3H]batrachotoxinin A 20 α-benzoate binding to sodium channels and inhibit sodium channel function","year":2008,"lang":"en","type":"article","venue":"Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology","topic":"Cannabis and Cannabinoid Research","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Veratridine; Sodium channel; Chemistry; AM251; Cannabinoid; Agonist; Cannabinoid receptor type 2; Stereochemistry; Batrachotoxin; Pharmacology; Cannabinoid receptor; Receptor; Sodium; Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003443619,0.0006319324,0.0006996148,0.0006390431,0.0009545289,0.0008146049,0.0009664361,0.0007524926,0.003473334],"category_scores_gemma":[0.0006627568,0.0008363975,0.0006875625,0.0007814968,0.001109221,0.0009061262,0.0004233096,0.001768864,0.001229077],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001562639,"about_ca_system_score_gemma":0.001485433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008542941,"about_ca_topic_score_gemma":0.01925215,"domain_scores_codex":[0.9993029,0.0001324904,0.00004779303,0.00007142837,0.0001418634,0.0003035849],"domain_scores_gemma":[0.999585,0.0001447299,0.00007748444,0.00007897621,0.00003475933,0.00007905903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002496116,0.0001350965,0.0003208676,0.00006238178,0.00003806829,0.0001781369,0.0001092015,0.0001434221,0.9936416,0.0009098105,0.0001468546,0.001818544],"study_design_scores_gemma":[0.0001576182,0.000666906,0.004881244,0.000009471633,0.00005353558,0.0004197458,0.0001054258,0.0009925477,0.9907902,0.0002560552,0.001643906,0.00002345773],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989166,0.002490374,0.002070154,0.0002903596,0.0001195437,0.00004207552,0.0004187,0.0001003286,0.005302455],"genre_scores_gemma":[0.9840211,0.003559258,0.002692738,0.0001846192,0.00004520963,0.00006793834,0.001115243,0.00006546758,0.00824845],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008542941,"threshold_uncertainty_score":0.01698643,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03335990169615937,"score_gpt":0.3101587738171243,"score_spread":0.2767988721209649,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}