{"id":"W2023326716","doi":"10.1371/journal.ppat.1004024","title":"Different Mutagenic Potential of HIV-1 Restriction Factors APOBEC3G and APOBEC3F Is Determined by Distinct Single-Stranded DNA Scanning Mechanisms","year":2014,"lang":"en","type":"article","venue":"PLoS Pathogens","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":67,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; National Institutes of Health","keywords":"APOBEC3G; DNA; Human immunodeficiency virus (HIV); Genetics; Biology; Chemistry; Computational biology; Virology; Cytidine deaminase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009236852,0.0002480317,0.0003683463,0.0001162257,0.0002181626,0.00001951139,0.0001253007,0.000187429,0.0002619646],"category_scores_gemma":[0.00008611273,0.0001926738,0.0001264908,0.00008106615,0.000129596,0.00004991466,0.00007463902,0.0001626587,0.00006815005],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005676579,"about_ca_system_score_gemma":0.00001882294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005267931,"about_ca_topic_score_gemma":0.00002041695,"domain_scores_codex":[0.9985559,0.0002369608,0.0002951087,0.0003831811,0.00009976701,0.0004290842],"domain_scores_gemma":[0.9993554,0.0001218744,0.0001314801,0.0002571151,0.0000517308,0.00008244334],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001270087,0.0003891185,0.009935001,0.00003332652,0.0002298161,0.000007043363,0.0002542582,4.697048e-7,0.9864317,0.0000175802,0.0001765212,0.002398178],"study_design_scores_gemma":[0.002263856,0.0009982962,0.04907566,0.00004615539,0.0002495782,0.00001699034,0.0001339086,0.00007602089,0.9465669,0.0001451093,0.0001997361,0.0002277363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953938,0.0002207882,0.00275435,0.00005623115,0.0001317106,0.0002959455,0.0009696218,0.00005843467,0.0001191095],"genre_scores_gemma":[0.9986373,0.00004312514,0.00007701595,0.00001213098,0.00001749157,0.0000227474,0.0007700087,0.00002419128,0.0003960225],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03986472,"threshold_uncertainty_score":0.785701,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01623487411858763,"score_gpt":0.216894639131802,"score_spread":0.2006597650132144,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}