{"id":"W2023347240","doi":"10.1021/pr7006363","title":"Tandem Immunoprecipitation of Phosphotyrosine-Mass Spectrometry (TIPY-MS) Indicates C19ORF19 Becomes Tyrosine-Phosphorylated and Associated with Activated Epidermal Growth Factor Receptor","year":2008,"lang":"en","type":"article","venue":"Journal of Proteome Research","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Princess Margaret Cancer Centre; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Immunoprecipitation; Epidermal growth factor receptor; Phosphorylation; Chemistry; Tandem mass spectrometry; Tyrosine kinase; Epidermal growth factor; Tyrosine; Signal transduction; Receptor tyrosine kinase; Receptor; Molecular biology; Biochemistry; Mass spectrometry; Biology; Cancer research; Gene; Chromatography","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001659244,0.0003893161,0.0002817119,0.000304728,0.0002662737,0.0002064835,0.0002290474,0.000330891,0.002415897],"category_scores_gemma":[0.000232975,0.000111838,0.0002917692,0.0001787201,0.0001994625,0.0001980911,0.0001911231,0.0006202931,0.0007683369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003564723,"about_ca_system_score_gemma":0.0001137754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005141819,"about_ca_topic_score_gemma":0.001236271,"domain_scores_codex":[0.9998662,0.00001119937,0.000008296579,0.00004973235,0.00003574801,0.00002865132],"domain_scores_gemma":[0.99989,0.00002293209,0.00003269375,0.00001005458,0.00001536622,0.00002896818],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001029332,0.0000165476,0.0007993589,0.00001577238,0.000007785355,0.0001973777,0.00000895877,0.00002565044,0.9972748,0.00004812283,0.0001139627,0.001388727],"study_design_scores_gemma":[0.0000192634,0.0001587663,0.02333093,0.000003697616,0.0000240255,0.00135581,0.00002088186,0.001554274,0.9718211,0.00008395663,0.00162124,0.000006053242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870387,0.0006043427,0.009664528,0.000207471,0.00005482246,0.00003034486,0.00121576,0.0001622811,0.001021854],"genre_scores_gemma":[0.9822866,0.0004718036,0.0125327,0.0001237917,0.00002949887,0.00003060175,0.002316493,0.00005389101,0.002154573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002415897,"threshold_uncertainty_score":0.008081973,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05143523750467856,"score_gpt":0.3319258141113755,"score_spread":0.280490576606697,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}