{"id":"W2023382272","doi":"10.1016/j.copbio.2008.10.006","title":"Novel anti-infectives: is host defence the answer?","year":2008,"lang":"en","type":"review","venue":"Current Opinion in Biotechnology","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":85,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Canada Research Chairs; Canadian Institutes of Health Research; Genome British Columbia; Bill and Melinda Gates Foundation; Foundation for the National Institutes of Health","keywords":"Innate immune system; Biology; Immunity; Pattern recognition receptor; Broad spectrum; Inflammation; Host (biology); Immune system; Immunology; Host response; Antimicrobial; Microbiology; Genetics; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.0001484,0.0006841626,0.001680644,0.0006059665,0.0003334242,0.00002392025,0.001075756,0.001962089,0.000122652],"category_scores_gemma":[0.00009875553,0.0004694321,0.0005530397,0.0007599374,0.001736335,0.00009512718,0.0005328884,0.002469073,0.0007309387],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001314995,"about_ca_system_score_gemma":0.0002605629,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007816338,"about_ca_topic_score_gemma":0.000003780013,"domain_scores_codex":[0.9973801,0.0002004516,0.000783764,0.0008631811,0.00004781564,0.0007246922],"domain_scores_gemma":[0.9982572,0.0002944012,0.0005458214,0.0008407991,0.00004382395,0.00001797343],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000092021,0.0004633364,0.00005368998,0.003629245,0.0002589003,0.000001962958,0.0002181049,3.41011e-7,0.0007073609,0.004181123,0.04115991,0.9493168],"study_design_scores_gemma":[0.0003441628,0.00007471714,0.00003446021,0.006709746,0.00005313339,0.0007373661,0.00007619608,4.888608e-7,0.0004634951,0.00002936313,0.9909721,0.0005047526],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000595678,0.9883792,0.0002868817,0.0003966384,0.009389728,0.0008756028,0.0003495541,0.0001790657,0.00008377142],"genre_scores_gemma":[0.0001512558,0.9990426,0.00003001772,0.00003993205,0.0001765624,0.0001123932,0.0002585606,0.00005236361,0.0001363518],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9498122,"threshold_uncertainty_score":0.9998323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07005782995058467,"score_gpt":0.3373506129249715,"score_spread":0.2672927829743868,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}