{"id":"W2023394177","doi":"10.1021/bi7006228","title":"The P-Glycoprotein (ABCB1) Linker Domain Encodes High-Affinity Binding Sequences to α- and β-Tubulins","year":2007,"lang":"en","type":"article","venue":"Biochemistry","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Linker; Amino acid; Peptide sequence; Biology; Cyclic nucleotide-binding domain; Glycoprotein; Plasma protein binding; Binding domain; Biochemistry; P-glycoprotein; Chemistry; Molecular biology; Binding site; Gene; Multiple drug resistance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000596579,0.0001611764,0.0001798576,0.00003225511,0.0002616656,0.00003599116,0.0001264359,0.0001571449,0.00003569565],"category_scores_gemma":[0.00006072738,0.0001056346,0.00005652678,0.0001797859,0.0001184886,0.00002332729,0.00002960793,0.000197556,0.00001988528],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005541523,"about_ca_system_score_gemma":0.00008724618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003098549,"about_ca_topic_score_gemma":0.00005397134,"domain_scores_codex":[0.9988476,0.000007906825,0.0002388377,0.0002898031,0.0002637151,0.0003521307],"domain_scores_gemma":[0.9993024,0.0000671064,0.00005566927,0.0002776035,0.00005209566,0.0002451587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002322111,0.00004119924,0.003083103,0.0001086911,0.00003172339,0.0001229848,0.0001826076,2.647649e-7,0.9929475,0.0007062694,0.0001930992,0.002350352],"study_design_scores_gemma":[0.000500915,0.00006872891,0.005814171,0.0001731479,0.00002938835,0.00003749274,0.0009386194,0.000001485568,0.9859218,0.0005805165,0.005764733,0.0001690126],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9936681,0.0005650413,0.0009718785,0.001629634,0.0001552237,0.0002515226,0.00001186434,0.00006919075,0.002677524],"genre_scores_gemma":[0.9877766,0.00009071593,0.008131101,0.0001931865,0.0003024849,0.00001560378,0.0000187865,0.00001699126,0.003454563],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007159222,"threshold_uncertainty_score":0.4307652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007347312012344303,"score_gpt":0.2484021547586822,"score_spread":0.2410548427463378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}