{"id":"W2023446937","doi":"10.1016/j.abb.2011.01.018","title":"The myosin phosphatase targeting protein (MYPT) family: A regulated mechanism for achieving substrate specificity of the catalytic subunit of protein phosphatase type 1δ","year":2011,"lang":"en","type":"review","venue":"Archives of Biochemistry and Biophysics","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":236,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Phosphatase; Protein subunit; Myosin; Protein phosphatase 2; Substrate (aquarium); Mechanism (biology); Substrate specificity; Chemistry; Biochemistry; Cell biology; Enzyme; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003013773,0.0004336994,0.0007414788,0.00003088755,0.0002112517,0.00001978134,0.0005957425,0.0002640692,0.000001648036],"category_scores_gemma":[0.0001882752,0.0002862417,0.00048827,0.0002383391,0.0006583877,0.000006931184,0.000308611,0.0002195992,2.962283e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008953122,"about_ca_system_score_gemma":0.0003490139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003324456,"about_ca_topic_score_gemma":0.000001437006,"domain_scores_codex":[0.9980941,0.0001239539,0.000821372,0.0004880118,0.0001681958,0.000304374],"domain_scores_gemma":[0.9976106,0.00007113641,0.001290076,0.0007785673,0.0001667259,0.00008294512],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002823932,0.0001219636,0.000001315413,0.01040569,0.0002508366,8.829485e-7,0.00003272968,0.000001181723,0.9121878,0.00416717,0.00001507113,0.07253303],"study_design_scores_gemma":[0.0003041186,0.0001487854,0.0000029905,0.004149795,0.0002554895,0.000003412206,0.00004375031,0.00003098448,0.9799606,0.001240175,0.01355863,0.000301323],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0614293,0.93468,0.0002702641,0.00001358231,0.00005942671,0.002128476,0.001334057,0.000009377863,0.00007554322],"genre_scores_gemma":[0.3631573,0.6312449,0.002039997,0.0000121658,0.0002543714,0.0002192432,0.002530356,0.0001057272,0.0004359282],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.3034351,"threshold_uncertainty_score":0.999959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02126660968759107,"score_gpt":0.2490218155988931,"score_spread":0.2277552059113021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}